Safety Assessment of Alkane Diols as Used in Cosmetics.

IF 1.2 4区医学 Q4 PHARMACOLOGY & PHARMACY

International Journal of Toxicology Pub Date : 2024-04-01 Epub Date: 2024-01-04 DOI:10.1177/10915818231224234

Laura N Scott, Monice Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Bart Heldreth

引用次数: 0

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 10 alkane diol ingredients as used in cosmetics. The alkane diols are structurally related to each other as small diols, and most are reported to function in cosmetics as solvents. The Panel reviewed the relevant data for these ingredients, and concluded that seven alkane diols are safe in cosmetics in the present practices of use and concentration described in this safety assessment, but that the available data are insufficient to make a determination of safety for three ingredients, namely 1,4-Butanediol, 2,3-Butanediol, and Octanediol.

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化妆品中使用的烷二醇安全性评估。

化妆品成分安全专家小组（专家小组）评估了化妆品中使用的 10 种烷二醇成分的安全性。这些烷二醇在结构上相互关联，都是小的二元醇，据报道，大多数烷二醇在化妆品中起溶剂作用。专家小组审查了这些成分的相关数据，得出结论认为，按照本安全评估中所述的现行使用方法和浓度，七种烷二醇在化妆品中是安全的，但现有数据不足以确定三种成分（即 1,4-丁二醇、2,3-丁二醇和辛二醇）的安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Toxicology 医学-毒理学

CiteScore

3.40

自引率

4.50%

发文量

审稿时长

4.5 months

期刊介绍： The International Journal of Toxicology publishes timely, peer-reviewed papers on current topics important to toxicologists. Six bi-monthly issues cover a wide range of topics, including contemporary issues in toxicology, safety assessments, novel approaches to toxicological testing, mechanisms of toxicity, biomarkers, and risk assessment. The Journal also publishes invited reviews on contemporary topics, and features articles based on symposia. In addition, supplemental issues are routinely published on various special topics, including three supplements devoted to contributions from the Cosmetic Review Expert Panel.