Association between night work and prostate cancer: a systematic review and meta-analysis.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Archives of Occupational and Environmental Health Pub Date : 2024-03-01 Epub Date: 2024-01-04 DOI:10.1007/s00420-023-02037-9

Alexander Jahn, Mathilde Lumbye Nielsen, Marianne Kyndi, Annett Dalbøge

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引用次数: 0

Abstract

Objective: The aim was to conduct a systematic review and meta-analysis to study the association between night work and the development of prostate cancer.

Methods: A systematic literature search was conducted in CINAHL, Embase, MEDLINE, and Web of Science. Studies were included based on a PECOS; the population included men in/above the working age, exposure defined as night work, outcome defined as prostate cancer, and study design restricted to cohort studies. The exclusion of articles, risk-of-bias assessment, and data extraction were performed by two reviewers. A meta-analysis was conducted using a random-effects model, including a sensitivity analysis stratified based on the risk-of-bias assessment. We evaluated publication bias using a funnel plot and Egger´s test, and the level of evidence was assessed using GRADE.

Results: A total of 528 articles were identified, and eight cohort studies were included. Three studies had a moderate risk of bias, while five studies had a high risk of bias. The meta-analysis showed a pooled hazard ratio (HR) of 1.0 (95% CI 0.6-1.7). In the sensitivity analysis, moderate vs. high risk-of-bias studies showed a pooled HR of 1.2 (95% CI 0.3-4.1) and 0.9 (95% CI 0.6-1.3), respectively. Based on GRADE, the level of evidence was rated low.

Conclusion: We found no association between night work and the development of prostate cancer. The evidence was assessed as limited and inconsistent. Future studies encompassing consistent definitions of night work, including objective exposure data, are highly warranted.

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夜间工作与前列腺癌之间的关系：系统回顾与荟萃分析。

目的：旨在对夜间工作与前列腺癌发病之间的关系进行系统回顾和荟萃分析：目的是对夜间工作与前列腺癌发病之间的关系进行系统回顾和荟萃分析：在 CINAHL、Embase、MEDLINE 和 Web of Science 中进行了系统性文献检索。纳入的研究基于 PECOS；研究人群包括工作年龄内/外的男性，研究暴露定义为夜间工作，研究结果定义为前列腺癌，研究设计仅限于队列研究。文章的排除、偏倚风险评估和数据提取由两名审稿人完成。我们采用随机效应模型进行了荟萃分析，包括根据偏倚风险评估进行分层的敏感性分析。我们使用漏斗图和 Egger´s 检验评估了发表偏倚，并使用 GRADE 评估了证据水平：结果：共发现了 528 篇文章，其中包括 8 项队列研究。三项研究存在中度偏倚风险，五项研究存在高度偏倚风险。荟萃分析显示，汇总的危险比（HR）为 1.0（95% CI 0.6-1.7）。在敏感性分析中，中度偏倚风险与高度偏倚风险研究的汇总 HR 分别为 1.2（95% CI 0.3-4.1）和 0.9（95% CI 0.6-1.3）。根据 GRADE，证据等级被评为低：我们没有发现夜间工作与前列腺癌的发生有任何关系。证据被评定为有限且不一致。未来的研究需要对夜间工作进行统一定义，包括客观的暴露数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.