Risk Factors for a Narrow Safety Margin after Endoscopic Submucosal Dissection for Early Gastric Cancer.

IF 2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Digestive Diseases Pub Date : 2024-01-01 Epub Date: 2024-01-03 DOI:10.1159/000536053

Min Kyung Yeo, Sun Hyung Kang, Hyun Seok Lee, Hyuk Soo Eun, Hee Seok Moon, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong

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引用次数: 0

Abstract

Introduction: A narrow safety margin (NSM) after endoscopic submucosal dissection (ESD) is a well-recognized risk factor for local recurrence in early gastric cancer (EGC). However, only a few studies have investigated the risk factors for the development of NSM.

Methods: The medical records and pathologic specimens of patients with EGC who underwent ESD from January 2020 to December 2020 at a single tertiary hospital (Daejeon, South Korea) were reviewed.

Results: A total of 218 patients were enrolled and 29 had NSM (<3 mm). When comparing the NSM and the control groups, the size of the lesion, the depth of invasion, and the operating endoscopist were found to be risk factors for the development of NSM. The increased length of the subepithelial spread of the lesion was associated with a narrower safety margin. Logistic regression analysis revealed that lesion size was a risk factor for NSM, and a marginally significant difference between endoscopists was found.

Conclusions: Multiple factors may need to be considered during ESD, including lesion size, invasion depth, operating endoscopist, and subepithelial spread.

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早期胃癌内镜黏膜下剥离术后安全范围狭窄的风险因素。

简介：内镜黏膜下剥离术（ESD）后的狭窄安全边缘（ESM）是公认的早期胃癌（ESC）局部复发的风险因素。然而，只有少数研究调查了发生 NSM 的风险因素：方法：回顾性分析一家三甲医院（韩国大田）在 2020 年 1 月至 2020 年 12 月期间接受 ESD 治疗的 EGC 患者的病历和病理标本：共有218名患者接受了ESD治疗，其中29名患者患有NSM（小于3毫米）。在对 NSM 组和对照组进行比较时发现，病变的大小、侵犯的深度和操作内镜的医生都是 NSM 发生的风险因素。病灶上皮下扩散长度的增加与安全范围的缩小有关。逻辑回归分析表明，病灶大小是NSM的风险因素，内镜医师之间的差异略有显著性：结论：ESD过程中可能需要考虑多种因素，包括病灶大小、侵犯深度、操作内镜医师和上皮下扩散。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive Diseases 医学-胃肠肝病学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Each issue of this journal is dedicated to a special topic of current interest, covering both clinical and basic science topics in gastrointestinal function and disorders. The contents of each issue are comprehensive and reflect the state of the art, featuring editorials, reviews, mini reviews and original papers. These individual contributions encompass a variety of disciplines including all fields of gastroenterology. ''Digestive Diseases'' bridges the communication gap between advances made in the academic setting and their application in patient care. The journal is a valuable service for clinicians, specialists and physicians-in-training.