Benign and malignant prostate neoplasms show different spatial organization of collagen.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Croatian Medical Journal Pub Date : 2023-12-31

Taras Zadvornyi, Nataliia Lukianova, Oleksandr Mushii, Anna Pavlova, Olena Voronina, Vasyl Chekhun

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引用次数: 0

Abstract

Aim: To compare the indicators of the spatial organization of collagen and its regulating factors between benign and malignant prostate neoplasms.

Methods: The study involved tumor tissue samples from 40 patients with stage II-III prostate cancer (PCa) and 20 patients with benign prostatic hyperplasia (BPH). The localization of collagen was determined with a Masson trichrome stain. To establish quantitative indicators of the spatial organization of collagen, morphometric studies were carried out with the CurveAlign and ImageJ programs.

Results: PCa tissue had two times lower collagen density (P<0.0001) and 1.3 times lower levels of collagen alignment (P=0.018) compared with BPH tissue. In PCa tissue, collagen fibers were shorter (by 24.2%; P<0.001) and thicker (by 15.5%; P<0.001). PCa tissue samples showed significantly higher levels of metalloproteinase (MMP)-2 (by 2.4 times; P=0.001), MMP-8 (by 2.3 times; P=0.007), and MMP-13 (by 1.9 times; P=0.004).

Conclusions: Collagen matrix spatial organization features, as well as its regulatory factors, could be potential biomarkers of malignant prostate neoplasms.

本刊更多论文

良性和恶性前列腺肿瘤显示出不同的胶原蛋白空间组织。

目的：比较良性和恶性前列腺肿瘤中胶原蛋白的空间组织指标及其调节因素：研究涉及 40 名 II-III 期前列腺癌（PCa）患者和 20 名良性前列腺增生（BPH）患者的肿瘤组织样本。采用马森三色染色法确定胶原蛋白的定位。为了确定胶原蛋白空间组织的定量指标，使用 CurveAlign 和 ImageJ 程序进行了形态计量学研究：结果：PCa 组织的胶原蛋白密度（PConclusions：胶原基质空间组织特征及其调控因子可能是恶性前列腺肿瘤的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Croatian Medical Journal 医学-医学：内科

CiteScore

3.00

自引率

5.30%

发文量

105

审稿时长

6-12 weeks

期刊介绍： Croatian Medical Journal (CMJ) is an international peer reviewed journal open to scientists from all fields of biomedicine and health related research. Although CMJ welcomes all contributions that increase and expand on medical knowledge, the two areas are of the special interest: topics globally relevant for biomedicine and health and medicine in developing and emerging countries.