Transversal Perspectives of Integrative Oncology Care in Gastric and Lobular Breast Cancer.

Q2 Medicine

Cancer treatment and research Pub Date : 2023-01-01 DOI:10.1007/978-3-031-33602-7_4

Emilio Francesco Giunta, Gianluca Arrichiello, Annalisa Pappalardo, Piera Federico, Angelica Petrillo

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Abstract

The occurrence of gastric cancer has been associated with an increased risk of lobular breast tumors in a subset of patients harboring selected germline mutations. Among all, the germline alteration of the gene coding for E-Cadherin (CDH1) was associated with an increased risk of gastric cancer diffuse-histotype and lobular breast cancer. However, the risk assessment of breast neoplasms and the role of multiple prophylactic procedures in these patients has never been systematically addressed. In addition, the performance of the common screening procedures for lobular breast cancer like mammography is suboptimal. Therefore, recalling the need for a better articulation of the patient-centered strategies of surveillance for individuals with germline CDH1 and other similar alterations, to offer comprehensive approaches for prevention, early diagnosis, and treatment. Accordingly, this chapter aims to discuss the value and the role of integrated oncological care in the era of oncology sub-specializations. Additionally, it sheds light on how the harmonization across the health providers can enhance patient care in this setting.

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胃癌和叶状乳腺癌综合肿瘤治疗的横向视角。

在一些携带特定种系突变的患者中，胃癌的发生与乳腺小叶肿瘤风险的增加有关。其中，E-Cadherin（CDH1）编码基因的种系突变与胃癌弥漫组织型和乳腺小叶肿瘤风险的增加有关。然而，乳腺肿瘤的风险评估以及多重预防程序在这些患者中的作用却从未得到过系统的研究。此外，乳腺 X 射线照相术等常见的小叶乳腺癌筛查程序的效果也不尽如人意。因此，我们需要更好地阐明以患者为中心的策略，对具有种系 CDH1 和其他类似基因改变的患者进行监测，以提供预防、早期诊断和治疗的综合方法。因此，本章旨在讨论肿瘤亚专科时代综合肿瘤治疗的价值和作用。此外，它还揭示了在这种情况下，医疗服务提供者之间的协调如何能加强对患者的护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer treatment and research Medicine-Oncology

CiteScore

1.00

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0.00%

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