Genetic polymorphisms in CYP2B6 may be associated with lung cancer risk in the Chinese Han population.

Expert review of respiratory medicine Pub Date : 2023-12-01 Epub Date: 2024-01-04 DOI:10.1080/17476348.2024.2302199

Xiaoya Ma, Xufeng Zang, Leteng Yang, Wenqian Zhou, Yujie Li, Jie Wei, Jinping Guo, Junhui Han, Jing Liang, Tianbo Jin

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Abstract

Background: Our study aimed to elucidate the association between single nucleotide polymorphisms (SNPs) in CYP2B6 gene and susceptibility to lung cancer (LC).

Methods: Five SNPs in CYP2B6 were genotyped in Chinese Han population (507 cases and 505 controls) utilizing Agena MassARRAY. The relationship between these SNPs and LC susceptibility was assessed using odds ratios, 95% confidence intervals, and χ2 tests. Additionally, multifactor dimensionality reduction was employed to analyze SNP-SNP interactions. Bioinformatics methods were applied to investigate the function of these SNPs.

Results: We found that rs2099361 was associated with an increased susceptibility to LC in the codominant model (OR = 1.31, p = 0.045). Stratification analysis revealed the allele G at rs4803418 and the allele T at rs4803420 of CYP2B6 (BMI >24 kg/m²) were significantly linked to decreased susceptibility of LC. Conversely, the allele C at rs12979270 (BMI >24 kg/m²) showed increased susceptibility to LC. Moreover, a robust redundant relationship between rs12979270 and rs4803420 was identified in the study. According to the VannoPortal database, we found that rs4803420, rs12979270 and rs2099361 may modulate the binding affinity of LMNB1, SP1 and HDAC2, respectively.

Conclusions: Our results suggest that SNPs in the CYP2B6 gene play crucial roles in LC susceptibility.

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CYP2B6的基因多态性可能与中国汉族人群的肺癌风险有关。

研究背景我们的研究旨在阐明CYP2B6基因中单核苷酸多态性（SNPs）与肺癌易感性之间的关系：方法：利用 Agena MassARRAY 对中国汉族人群（507 例病例和 505 例对照）中 CYP2B6 基因的 5 个 SNPs 进行基因分型。方法：利用 Agena MassARRAY 对中国汉族人群（507 例病例和 505 例对照）中的 5 个 CYP2B6 SNPs 进行基因分型。此外，还采用了多因素降维分析 SNP-SNP 相互作用。应用生物信息学方法研究了这些SNPs的功能：我们发现，在共显模型中，rs2099361 与 LC 易感性增加有关（OR = 1.31，p = 0.045）。分层分析显示，CYP2B6 rs4803418 的等位基因 G 和 rs4803420 的等位基因 T（体重指数大于 24 kg/m2）与 LC 易感性的降低显著相关。相反，rs12979270 的等位基因 C（体重指数大于 24 kg/m2）则显示对 LC 的易感性增加。此外，研究还发现，rs12979270 与 rs4803420 之间存在稳健的冗余关系。根据 VannoPortal 数据库，我们发现 rs4803420、rs12979270 和 rs2099361 可分别调节 LMNB1、SP1 和 HDAC2 的结合亲和力：我们的研究结果表明，CYP2B6 基因中的 SNPs 在 LC 易感性中起着关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Expert review of respiratory medicine

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