OCCLUSIVE RETINAL VASCULITIS AS A PRESENTING FEATURE OF PRIMARY VITREORETINAL LYMPHOMA RELAPSE.

Q3 Medicine
Manasi Ketkar, Niroj Sahoo, Vishal Raval
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引用次数: 0

Abstract

Purpose: The aim of this study was to report a case of primary vitreoretinal lymphoma (PVRL) relapse presenting as occlusive retinal vasculitis with secondary neovascularization.

Methods: This study was a retrospective case report.

Results: A 40-year-old woman presented to the clinic with complaints of blurring of vision in the left eye for 4 months. Her best-corrected VA (BCVA) was 20/20 and 20/500 in the right and left eye, respectively. The vitreous cavities of both eyes showed vitreous opacities (2+). Both eyes fundus showed multifocal yellowish-white subretinal infiltration. A diagnostic vitreous and subretinal biopsy of the left eye revealed large lymphoid cells with CD-20 positivity, confirming the diagnosis of PVRL. The patient received 12 intravitreal methotrexate injections in both eyes over a course of 2 months, after which the lesions completely resolved. However, after 5 months, the left eye showed characteristic subretinal lesions along with perivascular exudates and retinal hemorrhages, diagnosed as PVRL relapse presenting as occlusive retinal vasculitis. Fluorescein angiography revealed retinal neovascularization, for which panretinal photocoagulation was performed along with repeated intravitreal methotrexate injections.

Conclusion: Primary vitreoretinal lymphoma is a great masquerader, and although rare, PVRL relapse can present as occlusive retinal vasculitis with secondary neovascularization, thereby delaying diagnosis and subsequent treatment.

闭塞性视网膜血管炎是原发性玻璃体视网膜淋巴瘤复发的一种表现特征。
目的:报告一例原发性玻璃体视网膜淋巴瘤(PVRL)复发,表现为闭塞性视网膜血管炎和继发性新生血管:回顾性病例报告:一名 40 岁的妇女因左眼视力模糊 4 个月前来就诊。她的左右眼最佳矫正视力(BCVA)分别为 20/20 和 20/500。双眼玻璃体腔均显示玻璃体混浊(2+)。双眼眼底均出现多灶性黄白色视网膜下浸润。左眼的玻璃体和视网膜下诊断性活检发现了CD20阳性的大块淋巴细胞,确诊为PVRL。患者在两个月的时间里接受了 12 次玻璃体内甲氨蝶呤(MTX)注射,之后病变完全消退。然而,5 个月后,左眼出现了特征性视网膜下病变、血管周围渗出和视网膜出血,被诊断为 PVRL 复发,表现为闭塞性视网膜血管炎。荧光素血管造影显示视网膜新生血管(NVE),为此进行了全视网膜光凝,并反复在玻璃体内注射MTX:结论:PVRL极易伪装,虽然罕见,但PVRL复发可表现为继发NVE的闭塞性视网膜血管炎,从而延误诊断和后续治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Retinal Cases and Brief Reports
Retinal Cases and Brief Reports Medicine-Ophthalmology
CiteScore
2.10
自引率
0.00%
发文量
342
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