Neurexin-1-dependent circuit activity is required for the maintenance of photoreceptor subtype identity in Drosophila

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Gabrielle Lim-Kian-Siang, Arianna R. Izawa-Ishiguro, Yong Rao
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Abstract

In the human and Drosophila color vision system, each photoreceptor neuron (cone cell in humans and R7/R8 photoreceptor cell in Drosophila) makes a stochastic decision to express a single photopigment of the same family with the exclusion of the others. While recent studies have begun to reveal the mechanisms that specify the generation of cone subtypes during development in mammals, nothing is known about how the mosaic of mutually exclusive cone subtypes is maintained in the mammalian retina. In Drosophila, recent work has led to the identification of several intrinsic factors that maintain the identity of R8 photoreceptor subtypes in adults. Whether and how extrinsic mechanisms are involved, however, remain unknown. In this study, we present evidence that supports that the Drosophila transsynaptic adhesion molecule Neurexin 1 (Dnrx-1) is required non-cell autonomously in R8p subtypes for the maintenance of R8y subtype identity. Silencing the activity of R8p subtypes caused a phenotype identical to that in dnrx-1 mutants. These results support a novel role for Nrx-1-dependent circuit activity in mediating the communication between R8 photoreceptor subtypes for maintaining the subtype identity in the retina.
果蝇感光器亚型特征的维持需要依赖 Neurexin-1 的回路活动
在人类和果蝇的色觉系统中,每个感光神经元(人类的视锥细胞和果蝇的 R7/R8 感光细胞)都会随机决定表达同族中的一种光色素,而不表达其他光色素。尽管最近的研究已开始揭示哺乳动物发育过程中指定锥体亚型生成的机制,但对哺乳动物视网膜中如何维持相互排斥的锥体亚型的镶嵌却一无所知。在果蝇中,最近的研究发现了几种内在因素,它们可以维持成年果蝇 R8 感光器亚型的特性。然而,外在机制是否以及如何参与其中仍是未知数。在本研究中,我们提出证据支持果蝇跨突触粘附分子 Neurexin 1(Dnrx-1)在 R8p 亚型中非细胞自主地维持 R8y 亚型的特性。抑制 R8p 亚型的活性会导致与 dnrx-1 突变体相同的表型。这些结果支持了 Nrx-1 依赖性回路活动在介导 R8 感光器亚型之间的交流以维持视网膜中亚型特征方面的新作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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