Motor function outcomes in children with open prenatal repair of Spina Bifida Aperta at 36-month follow-up: The Zurich cohort.

IF 0.8 Q4 PEDIATRICS
Brittany Brun, David A Wille, Sonja M Schauer, Ueli Moehrlen, Martin Meuli, Beatrice Latal, Beth Padden
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Abstract

Purpose: This study aimed to describe outcomes of motor function with a special focus on ambulation ability at 36 months among children with open prenatal repair of spina bifida aperta (SB).

Methods: A prospective cohort study was conducted including 87 patients with open prenatal repair of SB at the investigating center born between 2010 and 2018. Anatomic lesion level and motor function level in the neonatal period, as well as motor function level, ambulation status, and use of orthotics and assistive devices at 36 months were assessed.

Results: At 36 months, ambulation was assessed in 86 children; of those, 86% (n = 74) were ambulating. Independent of ambulation, orthotics were worn in 81.6% (71/87) and assistive devices in 47.1% (41/87). Children with a lower lumbar or sacral motor function level were the first to reach independent ambulation and were more likely to ambulate at 36 months than children with higher motor function levels (p = < .001). The anatomic lesion level determined on the neonatal MRI correlated with ambulation status at 36 months (p = < 0.001).

Conclusion: At 36 months, most children with open prenatal repair for SB showed favourable ambulation status. However, most still used assistive devices or orthotics. Anatomic lesion level on neonatal MRI, motor function level during the neonatal period, and motor function level at 36 months were associated with ambulation status at 36 months.

随访 36 个月的开放性产前脊柱裂修复术患儿的运动功能结果:苏黎世队列。
目的:本研究旨在描述开放性产前修复脊柱裂(SB)患儿的运动功能结果,特别关注患儿在36个月时的行走能力:研究中心对2010年至2018年间出生的87名开放性产前修复脊柱裂患者进行了前瞻性队列研究。评估了新生儿期的解剖病变水平和运动功能水平,以及36个月时的运动功能水平、行走状况、矫形器和辅助设备的使用情况:结果:对86名患儿在36个月时的行走情况进行了评估,其中86%(n=74)的患儿可以行走。81.6%的患儿(71/87)佩戴了矫形器,47.1%的患儿(41/87)佩戴了辅助器械。与运动功能水平较高的儿童相比,腰部或骶骨运动功能水平较低的儿童最先实现独立行走,并且在36个月时更有可能实现独立行走(P = 结论:与运动功能水平较高的儿童相比,腰部或骶骨运动功能水平较低的儿童最先实现独立行走:大多数接受开放性产前骶骨修复术的患儿在36个月时的行走状况良好。然而,大多数患儿仍在使用辅助器具或矫形器。新生儿磁共振成像的解剖病变程度、新生儿期的运动功能水平以及36个月时的运动功能水平与36个月时的行走状况有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.30
自引率
5.30%
发文量
139
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