Stimulant Treatment and Potential Adverse Outcomes in Pediatric Populations With Bipolar Disorder: A Systematic Review of the Literature.

IF 2.7 3区医学 Q2 PSYCHIATRY

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2023-12-29 DOI:10.1177/10870547231218045

Hannah O'Connor, Chloe Hutt Vater, Maura DiSalvo, Stephen V Faraone, Janet Wozniak

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引用次数: 0

Abstract

Objective: To explore outcomes of stimulant treatment for ADHD in pediatric populations with particular attention to bipolar disorder (BPD).

Method: We conducted a literature search of PubMed articles published prior to August 25, 2022 that focused on BPD, mania, and psychosis prior to, or as result of, stimulant treatment. We excluded studies: (1) unrelated to stimulants, (2) general stimulant research, (3) articles older than 40 years, (4) study protocols, or (5) case reports.

Results: A total of 11 articles met all inclusion/exclusion criteria. Some reports found stimulant treatment safe and well-tolerated in children with comorbid BPD and ADHD. Others found evidence of treatment-emergent mania (TEM), discontinuation, and other adverse events with stimulant treatment.

Conclusion: Poor outcomes associated with stimulant treatment in pediatric populations with BPD necessitate work to identify patients at risk of serious stimulant-related adverse events. Our results were limited by automated search filters and a pediatric, primarily male sample.

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双相情感障碍儿童群体中的兴奋剂治疗和潜在不良后果：文献的系统回顾。

目的：探讨刺激剂治疗儿童多动症的效果，尤其关注双相情感障碍（BPD）：探讨刺激剂治疗儿童多动症的效果，尤其关注双相情感障碍（BPD）：我们对 2022 年 8 月 25 日之前在 PubMed 上发表的文献进行了检索，这些文献主要关注刺激剂治疗前或治疗后的双相情感障碍、躁狂症和精神病。我们排除了以下研究：（1）与兴奋剂无关的研究；（2）一般性兴奋剂研究；（3）超过40年的文章；（4）研究方案；或（5）病例报告：共有 11 篇文章符合所有纳入/排除标准。一些报告发现，对于合并有 BPD 和 ADHD 的儿童，兴奋剂治疗安全且耐受性良好。其他一些报告则发现了刺激剂治疗引发躁狂症（TEM）、停药和其他不良事件的证据：结论：在患有 BPD 的儿科人群中，刺激剂治疗的效果不佳，因此有必要开展工作，识别有可能发生严重刺激剂相关不良事件的患者。我们的研究结果受到了自动搜索过滤器和主要为男性的儿科样本的限制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Attention Disorders PSYCHIATRY-

CiteScore

7.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.