Exploring the clinical significance of miR-148 expression variations in distinct subtypes of irritable bowel syndrome

IF 1 4区生物学 Q4 GENETICS & HEREDITY

Annals of Human Genetics Pub Date : 2023-12-31 DOI:10.1111/ahg.12543

Qun Ji, Fengxia Du, Yangyaxin Yu, Ying Li

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引用次数: 0

Abstract

Irritable bowel syndrome (IBS) belongs to chronic functional gastrointestinal diseases featured by abdominal pain and changes in bowel habits. This study aimed to investigate the clinical significance of serum miR-148 expression in different subtypes of IBS. We enrolled 86 IBS patients and 55 healthy controls. miR-148 expression levels were assessed in IBS patients classified into IBS-constipation (IBS-C), IBS-diarrhea (IBS-D), and IBS-mixed stool pattern (IBS-M) subtypes. Receiver-operating characteristic (ROC) curves were employed to evaluate the diagnostic potential of miR-148 in distinguishing among IBS subtypes. Additionally, we analyzed the correlation between miR-148 expression and clinical characteristics, including IBS symptom severity. miR-148 expression was highest in IBS-D (diarrhea) group, followed by IBS-M and IBS-C. With the exception of the IBS-C group, miR-148 expression was elevated in IBS patients compared to controls. ROC curve analysis demonstrated that serum miR-148 exhibited higher diagnostic accuracy for discriminating IBS-C and IBS-D than IBS-M. Correlation analysis revealed a positive relationship between serum miR-148 relative expression and IBS symptom severity system scores. Univariate logistic analysis indicated a positive association between miR-148 expression and IBS-D and a negative correlation with IBS-C. miR-148 expression exhibits differential patterns among IBS subtypes and holds a potential to distinguish IBS-C and IBS-D. Furthermore, miR-148 expression correlates with the severity of IBS symptoms.

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探索不同亚型肠易激综合征中 miR-148 表达变化的临床意义

肠易激综合征（IBS）属于以腹痛和排便习惯改变为特征的慢性功能性胃肠道疾病。本研究旨在探讨不同亚型肠易激综合征患者血清 miR-148 表达的临床意义。我们招募了 86 名 IBS 患者和 55 名健康对照者，评估了分为 IBS 便秘（IBS-C）、IBS 腹泻（IBS-D）和 IBS 混合大便模式（IBS-M）亚型的 IBS 患者的 miR-148 表达水平。我们利用接收方操作特征曲线（ROC）评估了 miR-148 在区分 IBS 亚型方面的诊断潜力。此外，我们还分析了 miR-148 表达与临床特征（包括 IBS 症状严重程度）之间的相关性。miR-148 在 IBS-D（腹泻）组中表达最高，其次是 IBS-M 和 IBS-C。与对照组相比，除 IBS-C 组外，其他 IBS 患者的 miR-148 表达均升高。ROC 曲线分析表明，在鉴别 IBS-C 和 IBS-D 时，血清 miR-148 的诊断准确率高于 IBS-M。相关性分析表明，血清 miR-148 的相对表达与肠易激综合征症状严重程度系统评分之间存在正相关。单变量逻辑分析表明，miR-148 的表达与 IBS-D 呈正相关，而与 IBS-C 呈负相关。此外，miR-148 的表达与肠易激综合征症状的严重程度相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Genetics 生物-遗传学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Annals of Human Genetics publishes material directly concerned with human genetics or the application of scientific principles and techniques to any aspect of human inheritance. Papers that describe work on other species that may be relevant to human genetics will also be considered. Mathematical models should include examples of application to data where possible. Authors are welcome to submit Supporting Information, such as data sets or additional figures or tables, that will not be published in the print edition of the journal, but which will be viewable via the online edition and stored on the website.