Lipid nanodomains and receptor signaling: From actin-based organization to membrane mechanics

IF 6 2区 生物学 Q1 CELL BIOLOGY
Changting Li , Yazmina Quintana Perez , Christophe Lamaze , Cedric M. Blouin
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引用次数: 0

Abstract

The plasma membrane serves as the primary barrier between the cell's interior and its external surroundings, which places it at the forefront of intercellular communication, receptor signal transduction and the integration of mechanical forces from outside. Most of these signals are largely dependent on the plasma membrane heterogeneity which relies on lipid-lipid and lipid-protein interactions and the lateral nano-distribution of lipids organized by the dynamic network of cortical actin. In this review, we undertake an in-depth exploration of recent discoveries, which contribute significantly to the evolution from raft model to lipid nanodomains. Specifically, we will focus on their role in membrane receptor-mediated signaling in the context of cell membrane mechanics.

脂质纳米域和受体信号:从基于肌动蛋白的组织到膜力学
质膜是细胞内部和外部环境之间的主要屏障,它处于细胞间通信、受体信号转导和整合外部机械力的最前沿。这些信号在很大程度上取决于质膜的异质性,而质膜的异质性依赖于脂质与脂质、脂质与蛋白质之间的相互作用,以及由皮质肌动蛋白动态网络组织的脂质横向纳米分布。在这篇综述中,我们将深入探讨最近的发现,这些发现对从筏模型到脂质纳米域的演变做出了重大贡献。具体而言,我们将重点探讨它们在细胞膜力学背景下由膜受体介导的信号传导中的作用。
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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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