Respiratory sinus arrhythmia in spontaneously breathing, unanesthetized newborn and adult Wistar rats

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-12-29 DOI:10.1016/j.resp.2023.104207

Nana Sato Hashizume, Yoichiro Kitajima, Ryoji Ide, Eishi Nakamura, Chikako Saiki

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引用次数: 0

Abstract

We examined respiratory sinus arrhythmia (RSA) and possible interaction with respiratory frequency (f_R) and heart rate (HR) in spontaneously breathing, unanesthetized newborn Wistar rats (2- to 5-day-old; n = 54) and the adult rats (8-week-old; n = 34). Instantaneous heart rate (inst-HR) was calculated as the reciprocal of the inter-beat-interval. For each breath, RSA was determined as the difference between the maximum and minimum inst-HR value. The absolute RSA or RSA% (RSA per HR) were calculated as the average RSA of 10 consecutive breaths. RSA (or RSA%) in the newborn rats was significantly lower than that in the adult rats. Correlation coefficient between RSA (or RSA%) and 1/f_R or HR/f_R, but not HR, was significant in newborn rats, whereas only that between RSA (or RSA%) and HR was significant in adult rats. The power spectrum density of heartbeat fluctuation was detectable in both age groups. The present findings suggest that RSA exists and could be influenced by f_R, rather than HR, in newborn rats.

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未经麻醉的新生大鼠和成年 Wistar 大鼠自主呼吸时的呼吸窦性心律失常

我们研究了自主呼吸、未麻醉的新生 Wistar 大鼠（2 至 5 天大；n=54）和成年大鼠（8 周大；n=34）的呼吸窦性心律失常（RSA）以及与呼吸频率（fR）和心率（HR）之间可能存在的相互作用。瞬时心率（inst-HR）按搏动间隔的倒数计算。每次呼吸的 RSA 值为 inst-HR 最大值与最小值之差。绝对 RSA 或 RSA%（每 HR 的 RSA）按连续 10 次呼吸的平均 RSA 计算。新生大鼠的 RSA（或 RSA%）明显低于成年大鼠。新生大鼠的 RSA（或 RSA%）与 1/fR 或 HR/fR 的相关系数显著，但与 HR 的相关系数不显著，而成年大鼠只有 RSA（或 RSA%）与 HR 的相关系数显著。两个年龄组的大鼠都能检测到心跳波动的功率谱密度。本研究结果表明，新生大鼠存在RSA，并且可能受fR而非HR的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.