Protein kinase CK2: An emerging regulator of cellular metabolism

IF 5 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioFactors Pub Date : 2023-12-29 DOI:10.1002/biof.2032
Huilin Deng, Xinrui Rao, Sijia Zhang, Leichong Chen, Yan Zong, Rui Zhou, Rui Meng, Xiaorong Dong, Gang Wu, Qianwen Li
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引用次数: 0

Abstract

The protein kinase casein kinase 2 (CK2) exerts its influence on the metabolism of three major cellular substances by phosphorylating essential protein molecules involved in various cellular metabolic pathways. These substances include hormones, especially insulin, rate-limiting enzymes, transcription factors of key genes, and cytokines. This regulatory role of CK2 is closely tied to important cellular processes such as cell proliferation and apoptosis. Additionally, tumor cells undergo metabolic reprogramming characterized by aerobic glycolysis, accelerated lipid β-oxidation, and abnormally active glutamine metabolism. In this context, CK2, which is overexpressed in various tumors, also plays a pivotal role. Hence, this review aims to summarize the regulatory mechanisms of CK2 in diverse metabolic pathways and tumor development, providing novel insights for the diagnosis, treatment, and prognosis of metabolism-related diseases and cancers.

Abstract Image

Abstract Image

蛋白激酶 CK2:新出现的细胞代谢调节器
蛋白激酶酪蛋白激酶 2(CK2)通过磷酸化参与各种细胞代谢途径的重要蛋白分子,对三种主要细胞物质的代谢产生影响。这些物质包括激素(尤其是胰岛素)、限速酶、关键基因的转录因子和细胞因子。CK2 的这种调节作用与细胞增殖和凋亡等重要的细胞过程密切相关。此外,肿瘤细胞还经历了以有氧糖酵解、加速脂质β-氧化和异常活跃的谷氨酰胺代谢为特征的代谢重编程。在这种情况下,在各种肿瘤中过度表达的 CK2 也发挥了关键作用。因此,本综述旨在总结 CK2 在不同代谢途径和肿瘤发生中的调控机制,为代谢相关疾病和癌症的诊断、治疗和预后提供新的见解。
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来源期刊
BioFactors
BioFactors 生物-内分泌学与代谢
CiteScore
11.50
自引率
3.30%
发文量
96
审稿时长
6-12 weeks
期刊介绍: BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease. The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements. In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.
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