Acromegaly increases depressive symptoms and reduces quality of life of cohabitants

IF 3.3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Pituitary Pub Date : 2023-12-30 DOI:10.1007/s11102-023-01376-7

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引用次数: 0

Abstract

Purpose

To assess how living with patients with acromegaly affects people’s psychology and quality of life (QoL).

Methods

Acromegaly patients and their cohabitants included in this study. Patients were administered Acromegaly Quality of Life Questionnaire (AcroQoL), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). Cohabitants were administered quality of life questionnaire (SF-36), BAI, BDI, and Zarit Caregiver Burden Interview (ZBI).

Results

This study included 84 patients with acromegaly and 84 cohabitants. Sixty-nine patients (n = 84, 82.1%) had an acromegalic appearance. Cohabitants who were affected by the acromegalic appearance had higher BAI, BDI, and ZBI scores than those who were not affected (p < 0.001 for all). Cohabitants who were affected by the acromegalic appearance had a significantly lower SF-36 score (p = 0.015). The BAI (r=-0.535, p < 0.001), BDI (r=-0.592, p < 0.001), and ZBI (r=-0.465, p < 0.001) scores of the cohabitants showed a negative correlation with AcroQoL. SF-36 scores showed correlation with AcroQoL (r = 0.387, p < 0.001).

Conclusion

The chronic process of acromegaly and the external appearance of patients with this disease can negatively affect both the patients and the people living with them. Physicians being aware of this effect and taking counteractive measures may contribute positively to the course of acromegaly.

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肢端肥大症会增加同居者的抑郁症状并降低其生活质量

摘要目的评估与肢端肥大症患者共同生活对患者心理和生活质量（QoL）的影响。方法研究对象包括肢端肥大症患者及其同居者。对患者进行肢端肥大症生活质量问卷调查（AcroQoL）、贝克焦虑量表（BAI）和贝克抑郁量表（BDI）。对同组患者进行了生活质量问卷（SF-36）、贝克焦虑量表（BAI）、贝克抑郁量表（BDI）和扎里特照顾者负担访谈（ZBI）。结果本研究包括 84 名肢端肥大症患者和 84 名同居者。69名患者（n = 84，82.1%）有肢端肥大症表现。受肢端肥大症影响的同居者的 BAI、BDI 和 ZBI 评分均高于未受影响者（P 均为 0.001）。肢端肥大症患者的 SF-36 评分明显较低（p = 0.015）。同居者的 BAI（r=-0.535，p <0.001）、BDI（r=-0.592，p <0.001）和 ZBI（r=-0.465，p <0.001）得分与 AcroQoL 呈负相关。SF-36 评分与 AcroQoL 呈相关性（r=0.387，p < 0.001）。结论肢端肥大症的慢性过程和患者的外在表现会对患者和患者家属产生负面影响。医生意识到这种影响并采取应对措施，可能会对肢端肥大症的治疗起到积极作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pituitary 医学-内分泌学与代谢

CiteScore

7.10

自引率

7.90%

发文量

审稿时长

6 months

期刊介绍： Pituitary is an international publication devoted to basic and clinical aspects of the pituitary gland. It is designed to publish original, high quality research in both basic and pituitary function as well as clinical pituitary disease. The journal considers: Biology of Pituitary Tumors Mechanisms of Pituitary Hormone Secretion Regulation of Pituitary Function Prospective Clinical Studies of Pituitary Disease Critical Basic and Clinical Reviews Pituitary is directed at basic investigators, physiologists, clinical adult and pediatric endocrinologists, neurosurgeons and reproductive endocrinologists interested in the broad field of the pituitary and its disorders. The Editorial Board has been drawn from international experts in basic and clinical endocrinology. The journal offers a rapid turnaround time for review of manuscripts, and the high standard of the journal is maintained by a selective peer-review process which aims to publish only the highest quality manuscripts. Pituitary will foster the publication of creative scholarship as it pertains to the pituitary and will provide a forum for basic scientists and clinicians to publish their high quality pituitary-related work.