Oral manifestations of amyloidosis and the diagnostic applicability of oral tissue biopsy

IF 2.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Thalita Soares Tavares, Adriana Aparecida Silva da Costa, Anna Luíza Damaceno Araújo, Lucas Lacerda de Souza, Maria Inês Mantuani Pascoaloti, Vanessa Fátima Bernardes, Maria Cássia Ferreira Aguiar, Pablo Agustin Vargas, Felipe Paiva Fonseca, Hélder Antônio Rebelo Pontes, Marcio Ajudarte Lopes, Alan Roger Santos-Silva, Tarcília Aparecida da Silva, Patrícia Carlos Caldeira
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引用次数: 0

Abstract

Background

Amyloidosis exhibits a variable spectrum of systemic signs and oral manifestations that can be difficult to diagnose. This study aimed to characterize the clinical, demographic, and microscopic features of amyloidosis in the oral cavity.

Methods

This collaborative study involved three Brazilian oral pathology centers and described cases with a confirmed diagnosis of amyloidosis on available oral tissue biopsies. Clinical data were obtained from medical records. H&E, Congo-red, and immunohistochemically stained slides were analyzed.

Results

Twenty-six oral biopsies from 23 individuals (65.2% males; mean age: 59.6 years) were included. Oral involvement was the first sign of the disease in 67.0% of cases. Two patients had no clinical manifestation in the oral mucosa, although the histological analysis confirmed amyloid deposition. Amyloid deposits were distributed in perivascular (88.0%), periacinar and periductal (80.0%), perineurial (80.0%), endoneurial (33.3%), perimuscular (88.2%), intramuscular (94.1%), and subepithelial (35.3%) sites as well as around fat cells (100.0%). Mild/moderate inflammation was found in 65.4% of cases and 23.1% had giant cells.

Conclusions

Amyloid deposits were consistently found in oral tissues, exhibiting distinct deposition patterns. Oral biopsy is less invasive than internal organ biopsy and enables the reliable identification of amyloid deposits even in the absence of oral manifestations. These findings corroborate the relevance of oral biopsy for the diagnosis of amyloidosis.

淀粉样变性的口腔表现和口腔组织活检的诊断适用性。
背景:淀粉样变性表现出多种多样的全身症状和口腔表现,很难诊断。本研究旨在描述口腔淀粉样变性的临床、人口统计学和显微特征:这项合作研究涉及巴西三家口腔病理中心,描述了通过现有口腔组织活检确诊为淀粉样变性的病例。临床数据来自医疗记录。对经 H&E、刚果红和免疫组化染色的切片进行了分析:结果:共纳入 23 人(65.2% 为男性,平均年龄为 59.6 岁)的 26 份口腔活组织切片。67.0%的病例以口腔受累为首发症状。两名患者的口腔黏膜没有临床表现,但组织学分析证实了淀粉样蛋白沉积。淀粉样蛋白沉积分布在血管周围(88.0%)、心周和导管周围(80.0%)、神经周围(80.0%)、内膜(33.3%)、肌肉周围(88.2%)、肌肉内(94.1%)和上皮下(35.3%)以及脂肪细胞周围(100.0%)。65.4%的病例存在轻度/中度炎症,23.1%的病例存在巨细胞:结论:淀粉样蛋白沉积始终存在于口腔组织中,并表现出不同的沉积模式。口腔活检比内脏活检创伤更小,即使没有口腔表现,也能可靠地识别淀粉样沉积物。这些发现证实了口腔活检与淀粉样变性病诊断的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.90
自引率
6.10%
发文量
121
审稿时长
4-8 weeks
期刊介绍: The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.
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