Antioxidant treatments in patients with oral submucous fibrosis: A systematic review

IF 2.7 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine Pub Date : 2023-12-28 DOI:10.1111/jop.13503

Martín Pérez-Leal, Federico Lanciano, Nicla Flacco, Cristina Estornut, María Carmen Carceller

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引用次数: 0

Abstract

Introduction

Oral submucous fibrosis (OSMF) is a well-known precancerous oral lesion, characterized by scarring, tissue fibrosis, and premalignant lesions. The goal of clinical treatment is to reduce inflammation and improve patients' quality of life by enhancing mouth opening among others. Antioxidant treatment has shown promising results in inducing regression of lesions and preventing OSMF in high-risk individuals. This study investigates the effectiveness of various antioxidant agents against OSMF.

Materials and Methods

The study followed PRISMA guidelines and searched three scientific databases: PubMed, Web of Science, and Scopus, using specific algorithms related to “antioxidant treatment,” “burning sensation,” and “mouth opening.” The quality assessment of controlled clinical studies adhered to Cochrane guidelines.

Results

The analysis included 19 clinical trials comparing different treatments, including various antioxidants. Aloe vera, curcumin, and lycopene, among others, showed positive outcomes in treating OSMF by improving burning sensation, mouth opening, tongue protrusion, and cheek flexibility.

Conclusion

Antioxidant therapies are found to be effective in treating OSMF, even when compared to conventional treatments such as corticosteroids. The study highlights the need for further research and standardization of clinical protocols.

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口腔黏膜下纤维化患者的抗氧化治疗：系统综述。

简介：口腔黏膜下纤维化（OSMF）是众所周知的口腔癌前病变：口腔黏膜下纤维化（OSMF）是一种众所周知的口腔癌前病变，以瘢痕、组织纤维化和癌前病变为特征。临床治疗的目标是减轻炎症，并通过提高患者的张口度等改善其生活质量。抗氧化剂治疗在诱导高危人群的病变消退和预防 OSMF 方面显示出良好的效果。本研究调查了各种抗氧化剂对 OSMF 的有效性：本研究遵循 PRISMA 指南，检索了三个科学数据库：PubMed、Web of Science 和 Scopus，并使用与 "抗氧化剂治疗"、"灼烧感 "和 "张口 "相关的特定算法。对照临床研究的质量评估遵循 Cochrane 指南：分析包括 19 项比较不同治疗方法的临床试验，其中包括各种抗氧化剂。芦荟、姜黄素和番茄红素等抗氧化剂通过改善灼烧感、张口度、舌前伸和颊部灵活性，在治疗OSMF方面显示出积极的效果：结论：即使与皮质类固醇等传统疗法相比，抗氧化疗法也能有效治疗OSMF。这项研究强调了进一步研究和规范临床方案的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.