Interaction between Neurogenic Pulmonary Edema and Thoracic 3 DRG Degeneration Following Spinal Subarachnoid Hemorrhage: First Experimental Study.

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY

Journal of neurological surgery. Part A, Central European neurosurgery Pub Date : 2024-04-15 DOI:10.1055/a-2235-8556

Deniz Sirinoglu, Buse Sarigul, Ayhan Kanat, Mehmet Dumlu Aydin, Rabia Demirtas

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引用次数: 0

Abstract

Background: Neurogenic pulmonary edema (NPE) following subarachnoid hemorrhage (SAH) is still one of the most catastrophic complications with high morbidity and mortality rates. Systemic sympathetic hyperactivity has been considered in the pathogenesis, but it has not been clarified. In this study, we investigate the relationship between the degeneration of the T3 dorsal root ganglion (DRG) and the development of NPE following spinal SAH.

Methods: The study was conducted on 23 rabbits. Five rabbits were used as the control group, 5 as the sham group (n = 5), and 13 as the study group. The correlation between the degenerated neuronal densities of the T3 nerve axons and neurons in the DRG and NPE scores was analyzed statistically.

Results: A correlation between the neuronal degeneration of the T3 nerve, its DRG, and high NPE scores was found in the study group and the sham group. Massive NPE was detected in the study group along with neural degeneration of T3 axons and ganglia.

Conclusion: The present study indicates that NPE and pulmonary artery vasospasm can be prevented by reducing T3 DRG degeneration.

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脊髓蛛网膜下腔出血后神经源性肺水肿与胸部 3 DRG 退化之间的相互作用；首次实验研究。

目的：蛛网膜下腔出血（SAH）后的神经源性肺水肿（NPE）仍是最具灾难性的并发症之一，其发病率和死亡率都很高。系统交感神经功能亢进被认为是其发病机制之一，但尚未得到明确。本研究探讨了脊髓 SAH 后 Th3 背根神经节（DRG）退化与 NPE 发病之间的关系：研究对象为 23 只兔子。方法：研究对象为 23 只兔子，其中 5 只作为对照组（n=5），其余分为 SHAM 组（n=5）和研究组（n=13）。统计分析了Th3神经轴突和DRG中神经元变性密度与NPE评分之间的相关性结果：研究组和 SHAM 组的 Th3 神经轴突及其 DRG 中的神经元变性与高 NPE 评分之间存在相关性。研究组在 Th3 轴突和神经节神经变性的同时检测到大量 NPE：本研究表明，神经源性肺水肿和肺动脉血管痉挛可以通过减少 Th3 DRG 的变性来预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of neurological surgery. Part A, Central European neurosurgery CLINICAL NEUROLOGY-SURGERY

CiteScore

2.30

自引率

0.00%

发文量

期刊介绍： The Journal of Neurological Surgery Part A: Central European Neurosurgery (JNLS A) is a major publication from the world''s leading publisher in neurosurgery. JNLS A currently serves as the official organ of several national neurosurgery societies. JNLS A is a peer-reviewed journal publishing original research, review articles, and technical notes covering all aspects of neurological surgery. The focus of JNLS A includes microsurgery as well as the latest minimally invasive techniques, such as stereotactic-guided surgery, endoscopy, and endovascular procedures. JNLS A covers purely neurosurgical topics.