Association of pre-/early pregnancy high blood pressure and pregnancy outcomes: a systemic review and meta-analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-12-01 Epub Date: 2023-12-27 DOI:10.1080/14767058.2023.2296366

Ming Jin, Xiaowen Liu, Xiaojing Liu, Yaxian Wu, Yali Zhang, Le Zhang, Zhiwen Li, Rongwei Ye, Nan Li

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引用次数: 0

Abstract

Background: Maternal high blood pressure (BP) was associated with adverse pregnancy outcomes. This study aimed to synthesize evidence on the association between high BP prior to or in early pregnancy with maternal and fetal complications.

Methods: We searched the cohort studies assessing the effect of high BP in the Medline, Embase, Web of Science and China National Knowledge Internet databases. A random-effects model was used to estimate the pooled odds ratios (ORs) with 95% confidence intervals (CIs). The protocol was registered in PROSPERRO (CRD 42023414945).

Results: 23 eligible studies were identified. High BP prior to or in early pregnancy was associated with higher odds of hypertensive disorders of pregnancy (OR 2.90, 95% CI 1.91-3.89), gestational hypertension (2.56, 2.01-3.12), preeclampsia (3.20, 2.66-3.74), gestational diabetes mellitus (1.71, 1.36-2.06), preterm birth (1.66, 1.39-1.93), stillbirth (2.01, 1.45-2.58) and neonatal intensive care unit admission (1.22, 1.08-1.37). Subgroup analyses indicated that pre-hypertension could significantly increase the odds of these outcomes except for stillbirth, though the odds were lower than hypertension.

Conclusions: High BP prior to or in early pregnancy was associated with adverse pregnancy outcomes and this association increased with hypertension severity. The findings emphasized an urgent need for heightened surveillance for maternal BP, especially pre-hypertensive status.

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孕前/孕早期高血压与妊娠结局的关系：系统回顾和荟萃分析。

背景：孕产妇高血压（BP）与不良妊娠结局有关。本研究旨在总结孕前或孕早期高血压与母体和胎儿并发症之间关系的证据：我们在 Medline、Embase、Web of Science 和中国知网数据库中检索了评估高血压影响的队列研究。采用随机效应模型估算出合并的几率比（ORs）及 95% 的置信区间（CIs）。研究方案已在 PROSPERRO（CRD 42023414945）上注册。孕前或孕早期血压高与妊娠高血压疾病（OR 2.90，95% CI 1.91-3.89）、妊娠高血压（2.56，2.01-3.12）、子痫前期（3.20，2.66-3.74）、妊娠糖尿病（1.71，1.36-2.06）、早产（1.66，1.39-1.93）、死胎（2.01，1.45-2.58）和新生儿重症监护室入院（1.22，1.08-1.37）。亚组分析表明，除死胎外，高血压前期可显著增加上述结果的几率，但几率低于高血压：结论：孕前或孕早期血压偏高与不良妊娠结局有关，且这种关联随着高血压严重程度的增加而增加。研究结果强调，迫切需要加强对孕产妇血压的监测，尤其是高血压前期状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.