Virucidal effect of mouthwash on acyclovir-resistant herpes simplex virus.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-10-01 Epub Date: 2023-12-27 DOI:10.1111/odi.14843

M Bar Ilan, S Dovrat, R Cohen, M Georgaki, E Papadopoulou, N G Nikitakis, N Yarom

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引用次数: 0

Abstract

Objectives: The symptoms of herpes simplex viruses type 1 (HSV-1) infections might be severe and persistent in immunocompromised patients in whom they reactivate at a high frequency. The development of Acyclovir (ACV) resistant strains due to long-term treatment with antiviral agents in those patients is not uncommon. The aim of the present study was to assess the virucidal effect of commercially available mouthwashes against ACV-resistant HSV-1 strains.

Materials and methods: Two acyclovir-resistant HSV-1 strains were exposed for 30 s to essential oil-based (Listerine Fresh Burst® and Listerine Zero®), chlorhexidine gluconate 0.2% (Hexidyl®) and povidone-iodine 7.5% (Betadine Gargle®) mouthwashes. Loss of virus infectivity was determined by means of plaque reduction assays in a cell culture system.

Results: All 4 of the tested solutions significantly reduced virus infectivity, with the essential oil-based and povidone-iodine mouthwashes being slightly more efficacious, compared to chlorhexidine.

Conclusion: The findings of this analysis revealed that the tested oral rinses demonstrated in-vitro antiviral activity against ACV-resistant HSV. Comparative clinical trials are required to establish the clinical effectiveness of daily use of oral rinses in reducing the appearance of oral HSV lesions in immunocompromised patients.

查看原文本刊更多论文

漱口水对阿昔洛韦耐药单纯疱疹病毒的杀病毒作用。

目的：单纯疱疹病毒 1 型（HSV-1）感染的症状在免疫力低下的患者中可能会很严重且持续存在，而这些患者的疱疹病毒 1 型会频繁再激活。这些患者因长期接受抗病毒药物治疗而产生阿昔洛韦（ACV）耐药株的情况并不少见。本研究旨在评估市售漱口水对阿昔洛韦耐药 HSV-1 株的杀病毒效果：将两种耐阿昔洛韦的 HSV-1 株系暴露于精油型（李施德林 Fresh Burst® 和李施德林 Zero®）、0.2% 葡萄糖酸氯己定 (Hexidyl®) 和 7.5% 聚维酮碘 (Betadine Gargle®) 漱口水 30 秒。通过在细胞培养系统中进行斑块减少试验来测定病毒的感染性：结果：所有 4 种测试溶液都能明显降低病毒的感染性，与洗必泰相比，精油型和聚维酮碘漱口水的效果稍好：分析结果表明，测试的口腔漱口水对耐 ACV HSV 具有体外抗病毒活性。要确定每天使用口腔漱口水对减少免疫力低下患者口腔 HSV 病变的临床疗效，还需要进行比较临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.