Discordance of Aqueous/Plasma HIV Replication on ART.

IF 0.8 4区医学 Q4 IMMUNOLOGY

Current HIV Research Pub Date : 2024-01-01 DOI:10.2174/011570162X268730231212112119

Xin Che, Luoziyi Wang, Weimei Ma, Rui Wang, Zhiliang Wang

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Abstract

Background: The study was conducted to analyze HIV dynamics across blood-retinal barrier (BRB) and the relevant risk factors for HIV-associated ocular complications.

Methods: This study included a case series of 40 HIV-positive patients with ocular lesions, which were studied retrospectively. Clinical and laboratory examinations included plasma and intraocular viral load (VL).

Results: HIV VL on paired aqueous/plasma samples was available for 40 patients. Aqueous VL was negatively associated with antiretroviral treatment (ART) duration (p = 0.02 and p < 0.05), and plasma VL was independent of ART duration (p = 0.53). An aqueous/plasma discordance was found in 19/40 (47.5%) patients, eight of whom (20%) had detectable aqueous VL despite a suppressed plasma VL (escape). There were significant differences in CD4+ T-lymphocyte levels (p = 0.011 and p < 0.05) and ART duration (p = 0.007 and p < 0.05) between the patients with HIV-associated ocular complications and the patients without.

Conclusion: This study provides a rationale for initiating ART early in the course of infection to reduce HIV VL in the aqueous humor, and raises the possibility of the ocular sanctuary where HIV replicates. Meanwhile, early and standard ART would be an optimal option to protect against ocular opportunistic infection.

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抗逆转录病毒疗法中水/血浆 HIV 复制的不一致性。

背景：本研究旨在分析艾滋病毒在血-视网膜屏障（BRB）上的动态变化以及导致艾滋病毒相关眼部并发症的相关风险因素：该研究旨在分析艾滋病病毒跨血液-视网膜屏障（BRB）的动态变化以及艾滋病病毒相关眼部并发症的相关风险因素：本研究包括 40 例眼部病变的 HIV 阳性患者的病例系列，并对其进行了回顾性研究。临床和实验室检查包括血浆和眼内病毒载量（VL）：结果：40 名患者的配对水样/血浆样本中均有 HIV VL。水样 VL 与抗逆转录病毒疗法（ART）持续时间呈负相关（p = 0.02 和 p < 0.05），血浆 VL 与抗逆转录病毒疗法持续时间无关（p = 0.53）。19/40（47.5%）名患者的水样 VL 与血浆 VL 不一致，其中 8 人（20%）尽管血浆 VL 已被抑制，但仍可检测到水样 VL（逃逸）。患有艾滋病相关眼部并发症的患者与未患有艾滋病相关眼部并发症的患者在 CD4+ T 淋巴细胞水平（p=0.011 和 p < 0.05）和抗逆转录病毒疗法持续时间（p=0.007 和 p < 0.05）方面存在明显差异：本研究为在感染早期开始抗逆转录病毒疗法以减少眼房水中的 HIV VL 提供了依据，并提出了眼部成为 HIV 复制圣地的可能性。同时，早期和标准的抗逆转录病毒疗法将是防止眼部机会性感染的最佳选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current HIV Research 医学-病毒学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.