Intravoxel Incoherent Motion Quantification Dependent on Measurement SNR and Tissue Perfusion: A Simulation Study.

Q3 Medicine

Journal of Biomedical Physics and Engineering Pub Date : 2023-12-01 DOI:10.31661/jbpe.v0i0.2102-1281

Sam Sharifzadeh Javidi, Alireza Shirazinodeh, Hamidreza Saligheh Rad

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引用次数: 0

Abstract

Background: The intravoxel incoherent motion (IVIM) model extracts both functional and structural information of a tissue using motion-sensitizing gradients.

Objective: The Objective of the present work is to investigate the impact of signal to noise ratio (SNR) and physiologic conditions on the validity of IVIM parameters.

Material and methods: This study is a simulation study, modeling IVIM at a voxel, and also done 10,000 times for every single simulation. Complex noises with various standard deviations were added to signal in-silico to investigate SNR effects on output validity. Besides, some blood perfusion situations for different tissues were considered based on their physiological range to explore the impacts of blood fraction at each voxel on the validity of the IVIM outputs. Coefficient variation (CV) and bias of the estimations were computed to assess the validity of the IVIM parameters.

Results: This study has shown that the validity of IVIM output parameters highly depends on measurement SNR and physiologic characteristics of the studied organ.

Conclusion: IVIM imaging could be useful if imaging parameters are correctly selected for each specific organ, considering hardware limitations.

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取决于测量信噪比和组织灌注的体外不相干运动定量：模拟研究

背景：体内非相干运动（IVIM体外非相干运动（IVIM）模型利用运动敏感梯度提取组织的功能和结构信息：本研究的目的是探讨信噪比（SNR）和生理条件对 IVIM 参数有效性的影响：本研究是一项模拟研究，对一个体素的 IVIM 进行建模，每一次模拟都要进行 10,000 次。为了研究信噪比对输出有效性的影响，在模拟信号中加入了不同标准差的复杂噪声。此外，还根据不同组织的生理范围，考虑了不同组织的血液灌注情况，以探讨每个体素的血液分量对 IVIM 输出有效性的影响。计算了估计值的变异系数（CV）和偏差，以评估 IVIM 参数的有效性：研究结果表明，IVIM 输出参数的有效性在很大程度上取决于测量信噪比和所研究器官的生理特征：结论：考虑到硬件的局限性，如果针对每个特定器官正确选择成像参数，IVIM成像可能会很有用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomedical Physics and Engineering Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Biomedical Physics and Engineering (JBPE) is a bimonthly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research (experimental or theoretical) broadly concerned with the relationship of physics to medicine and engineering.