Testicular dysfunction in experimental chronic renal insufficiency: a deficiency of nocturnal pineal N-acetyltransferase activity.

E W Holmes, S A Hojvat, S E Kahn, E W Bermes
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Abstract

Biochemical correlates of neuroendocrine/gonadal function and nocturnal levels of serotonin N-acetyltransferase (NAT) activity were determined in partially nephrectomized (PNx), male, Long Evans rats following a 5-week period of chronic renal insufficiency (CRI). PNx animals demonstrated two to four-fold elevations in urea nitrogen and three to four-fold reductions (P less than 0.02) in plasma total testosterone concentrations as compared to sham-operated controls. The pituitary LH contents of PNx rats were decreased to approximately 60% of the control value (P less than 0.05). There were no differences in plasma prolactin levels between the control and PNx groups either at mid-day or in the middle of the night. Nocturnal pineal NAT activity in PNx rats was markedly reduced to approximately 20% of the control value (P less than 0.001). Similar evidence of gonadal dysfunction (reduced plasma total testosterone and testes testosterone content) and a significant decrease in night-time levels of pineal NAT activity were also observed after 13 weeks of CRI in PNx rats of the Sprague-Dawley strain that were housed under a different photoperiod. These results suggest that pineal gland dysfunction is a feature of CRI in the PNx model. Such an abnormality might contribute to the pathogenesis of gonadal dysfunction in CRI.

实验性慢性肾功能不全的睾丸功能障碍:夜间松果体n -乙酰转移酶活性的缺乏。
研究了部分肾切除(PNx)雄性Long Evans大鼠慢性肾功能不全(CRI) 5周后,神经内分泌/性腺功能的生化相关指标和夜间血清素n -乙酰基转移酶(NAT)活性水平。与假手术对照组相比,PNx动物的尿素氮升高2 - 4倍,血浆总睾酮浓度降低3 - 4倍(P < 0.02)。PNx大鼠垂体LH含量降至对照组的60%左右(P < 0.05)。对照组和PNx组在中午和午夜的血浆催乳素水平没有差异。PNx大鼠夜间松果体NAT活性显著降低,约为对照组的20% (P < 0.001)。在不同光周期下饲养的Sprague-Dawley品种PNx大鼠,在CRI 13周后,也观察到类似的性腺功能障碍(血浆总睾酮和睾丸睾酮含量降低)和夜间松果体NAT活性水平显著下降的证据。这些结果表明,松果体功能障碍是PNx模型中CRI的一个特征。这种异常可能与CRI患者性腺功能障碍的发病机制有关。
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