An "on-off-on" Fluorescent Sensor Based on Carbon Dots for the Detection of Au (III) and Creatinine.

IF 2.6 4区化学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Fluorescence Pub Date : 2025-02-01 Epub Date: 2023-12-27 DOI:10.1007/s10895-023-03567-8

Zicheng Cai, Chun Zhu, Anqi Hu, Guoqing Chen

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Abstract

The present study proposes a new approach for detecting trace amounts of creatinine (Cre) through the utilization of a fluorescence sensor system consisting of nitrogen doped carbon dots (NCDs) and gold ions (Au³⁺). Yellow fluorescent carbon dots were prepared using a one-step hydrothermal method with o-phenylenediamine and isopropanol as raw materials. First, gold ions are reduced to gold nanoparticles (Au NPs), which bind to NCDs, resulting in electron transfer and fluorescence quenching of NCDs. After adding creatinine, Cre and Au NPs were preferentially combined to form non-fluorescent complexes, and the NCDs fluorescence was restored. The study achieved a detection limit of 1.06 × 10^-7 M for Au³⁺ and 9.29 × 10^-9 M for creatinine, indicating a high level of sensitivity. The sensing system has also been successfully utilized for detecting Au³⁺ in lake water and Cre in human urine, indicating its promising potential and practical applications in the areas of environmental monitoring and biosensing.

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基于碳点的 "开-关-开 "荧光传感器，用于检测金 (III) 和肌酐。

本研究提出了一种利用由掺氮碳点（NCD）和金离子（Au3+）组成的荧光传感器系统检测痕量肌酐（Cre）的新方法。以邻苯二胺和异丙醇为原料，采用一步水热法制备了黄色荧光碳点。首先，金离子被还原成金纳米粒子（Au NPs），金纳米粒子与 NCDs 结合，导致 NCDs 发生电子转移和荧光淬灭。加入肌酐后，Cre和Au NPs优先结合形成无荧光复合物，NCDs荧光恢复。研究结果表明，Au3+ 的检测限为 1.06 × 10-7 M，肌酐的检测限为 9.29 × 10-9 M，灵敏度很高。该传感系统还被成功用于检测湖水中的 Au3+和人体尿液中的 Cre，表明其在环境监测和生物传感领域具有广阔的潜力和实际应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Fluorescence 化学-分析化学

CiteScore

4.60

自引率

7.40%

发文量

203

审稿时长

5.4 months

期刊介绍： Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.