Vaccination time does not influence total anti-SARS-CoV-2 antibodies response.

IF 2.2 4区医学 Q2 BIOLOGY

Chronobiology International Pub Date : 2024-02-01 Epub Date: 2023-12-26 DOI:10.1080/07420528.2023.2298264

Laura Pighi, Simone De Nitto, Gian Luca Salvagno, Giuseppe Lippi

引用次数: 0

Abstract

We measured total anti-SARS-CoV-2 receptor-biding domain (RBD) antibodies in 249 healthcare workers (mean age: 44 ± 13 years; 151 women), who received the first dose of mRNA-based Comirnaty COVID-19 vaccine at different times of the day. Compared with the reference vaccination time point (i.e. <10:00h), vaccine injection at the following times of day elicited a comparable response (all p > 0.05). Under our experimental conditions, we can therefore exclude a possible influence of the timing of primary mRNA-based COVID-19 vaccination on the levels of total anti-SARS-CoV-2 antibodies.

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接种时间不会影响总的抗 SARS-CoV-2 抗体反应。

我们测量了 249 名医护人员（平均年龄：44 ± 13 岁；151 名女性）的总抗 SARS-CoV-2 受体引导结构域（RBD）抗体，他们在一天中的不同时间接种了第一剂基于 mRNA 的 Comirnaty COVID-19 疫苗。与参考接种时间点相比（即 p > 0.05）。因此，在我们的实验条件下，我们可以排除接种基于 mRNA 的 COVID-19 疫苗的时间对总抗 SARS-CoV-2 抗体水平的可能影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chronobiology International 生物-生理学

CiteScore

5.60

自引率

7.10%

发文量

110

审稿时长

1 months

期刊介绍： Chronobiology International is the journal of biological and medical rhythm research. It is a transdisciplinary journal focusing on biological rhythm phenomena of all life forms. The journal publishes groundbreaking articles plus authoritative review papers, short communications of work in progress, case studies, and letters to the editor, for example, on genetic and molecular mechanisms of insect, animal and human biological timekeeping, including melatonin and pineal gland rhythms. It also publishes applied topics, for example, shiftwork, chronotypes, and associated personality traits; chronobiology and chronotherapy of sleep, cardiovascular, pulmonary, psychiatric, and other medical conditions. Articles in the journal pertain to basic and applied chronobiology, and to methods, statistics, and instrumentation for biological rhythm study. Read More: http://informahealthcare.com/page/cbi/Description