Association between circulating unsaturated fatty acid and preeclampsia: a two-sample Mendelian randomization study.

IF 1.7 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Yixiao Wang, Sicong Liu, Chengqian Wu, Hong Yu, Xiaohong Ji
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引用次数: 0

Abstract

Objective: In recent years, several studies have reported an association between unsaturated fatty acids (UFAs) and the risk of developing preeclampsia; however, its exact causal effect is unclear. This study assessed the causal association between circulating UFAs and preeclampsia.

Methods: A two-sample Mendelian randomization (MR) study using publicly available genome-wide association study (GWAS) summary data for circulating UFA s (N = 114,999) and preeclampsia (N = 118,291) was performed. Single nucleotide polymorphisms (SNPs) significantly associated with exposure was selected as instrumental variables (IVs). The inverse variance weighted (IVW) test was used as the primary method for estimating causality in MR analysis, while MR pleiotropy residual sum and outlier (MR-PRESSO) and MR-Egger regression methods were used to assess horizontal pleiotropy. Cochran's Q test was used to evaluate heterogeneity among SNPs, and leave-one-out sensitivity analysis was used to determine the effect of individual SNPs on the results of the MR analysis. Bonferroni correction was used as a correction for multiple corrections.

Results: Two-sample MR analysis suggested that the ratio of monounsaturated fatty acids (MUFAs) to total fatty acids (OR 1.150, 95% CI 1.006-1.315, p = 0.041), the ratio of polyunsaturated fatty acids (PUFAs) to total fatty acids (OR 0.805, 95% CI 0.658-0.986, p = 0.036) and the ratio of PUFAs to MUFAs (OR 0.807, 95% CI 0.694-0.938, p = 0.005) were causally associated with preeclampsia. After Bonferroni correction, the causal association between the ratio of polyunsaturated to MUFAs and preeclampsia remained statistically different.

Conclusions: This MR analysis provides evidence for a genetic causal association between circulating UFAs and preeclampsia.

循环不饱和脂肪酸与先兆子痫之间的关系:双样本孟德尔随机研究。
目的:近年来,一些研究报道了不饱和脂肪酸(UFAs)与子痫前期发病风险之间的关系,但其确切的因果关系尚不清楚。本研究评估了循环中的不饱和脂肪酸与子痫前期之间的因果关系:利用公开的全基因组关联研究(GWAS)汇总数据,对循环 UFAs(N = 114999)和子痫前期(N = 118291)进行了双样本孟德尔随机化(MR)研究。选择与暴露显著相关的单核苷酸多态性(SNPs)作为工具变量(IVs)。反方差加权(IVW)检验是 MR 分析中估计因果关系的主要方法,而 MR 多效性残差和离群值(MR-PRESSO)和 MR-Egger 回归方法则用于评估水平多效性。Cochran's Q 检验用于评估 SNPs 之间的异质性,leave-one-out 敏感性分析用于确定单个 SNPs 对 MR 分析结果的影响。对多重校正采用了 Bonferroni 校正:双样本 MR 分析表明,单不饱和脂肪酸(MUFAs)与总脂肪酸之比(OR 1.150,95% CI 1.006-1.315,p = 0.041)、多不饱和脂肪酸(PUFAs)与总脂肪酸之比(OR 0.805,95% CI 0.658-0.986,p = 0.036)和 PUFAs 与 MUFAs 之比(OR 0.807,95% CI 0.694-0.938,p = 0.005)与子痫前期有因果关系。经过Bonferroni校正后,多不饱和脂肪酸与多不饱和脂肪酸的比率与先兆子痫之间的因果关系仍存在统计学差异:这项磁共振分析为循环中的多不饱和脂肪酸与先兆子痫之间的遗传因果关系提供了证据。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
217
审稿时长
2-3 weeks
期刊介绍: The official journal of The European Association of Perinatal Medicine, The Federation of Asia and Oceania Perinatal Societies and The International Society of Perinatal Obstetricians. The journal publishes a wide range of peer-reviewed research on the obstetric, medical, genetic, mental health and surgical complications of pregnancy and their effects on the mother, fetus and neonate. Research on audit, evaluation and clinical care in maternal-fetal and perinatal medicine is also featured.
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