Association of maternal and paternal personality disorders with risk of mental disorders in children: A nationwide, register-based cohort study of 1,406,965 children

IF 5.3 2区医学 Q1 PSYCHIATRY

Acta Psychiatrica Scandinavica Pub Date : 2023-12-25 DOI:10.1111/acps.13648

Ida Christine Tholstrup Gjøde, Thomas Munk Laursen, Anne Dorothee Müller, Anne Ranning, Mala Moszkowicz, Nicoline Hemager, Helene Speyer, Carsten Hjorthøj, Merete Nordentoft, Anne Amalie Elgaard Thorup

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Abstract

Background

Knowledge of the association between parental personality disorders and mental disorders in children is limited. To examine the association between parental personality disorders and the risk of mental disorders in offspring.

Methods

We linked Danish health registers to create a cohort of children born from January 1, 1995, to December 31, 2016. Children were followed until their 18th birthday, diagnosis set, emigration, death, or December 31, 2016. Parental personality disorders according to the International Classification of Diseases (ICD) Eighth or 10th Revision. Poisson regression analyses were used to estimate the incidence risk ratio (IRR) and cumulative incidence of ICD 10th mental disorders in offspring (age 0–17).

Results

The study cohort included 1,406,965 children. For girls, maternal or paternal personality disorder (MPD/PPD) was associated with mental disorders: MPD girls (IRR, 2.74; 95% CI, 2.59–2.89) and PPD girls (IRR, 2.10; 95% CI, 1.94–2.27). Likewise, the risk was increased for both MPD boys (IRR, 2.44; 95% CI, 2.33–2.56) and PPD boys (IRR, 2.04; 95% CI, 1.91–2.18). For girls and boys combined, exposure to two parents with a personality disorder was associated with the highest risk (IRR, 3.69; 95% CI, 3.15–4.33). At age 18, the cumulative incidence of any mental disorder in children of one or two parents with a personality disorder was 34.1% (95% CI, 33.0–35.1), which was twice the cumulative incidence of mental disorders in nonexposed children (15.2% [95% CI, 15.1–15.3]).

Conclusion

Children of parents with a personality disorder were at a 2 to 3.5 times higher risk of mental disorders compared with nonexposed offspring. Possible mechanisms of transmission of mental disorders from parent to child involve genetic, environmental, and gene–environment pathways. More research into these mechanisms and research into preventive interventions is warranted.

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母亲和父亲的人格障碍与儿童精神障碍风险的关系：对全国 1,406,965 名儿童进行的基于登记的队列研究。

背景：有关父母人格障碍与子女精神障碍之间关系的知识十分有限。目的：研究父母人格障碍与后代精神障碍风险之间的关系：我们将丹麦健康登记册联系起来，建立了一个从 1995 年 1 月 1 日至 2016 年 12 月 31 日出生的儿童队列。我们对这些儿童进行了跟踪调查，直至他们 18 岁生日、诊断确定、移民、死亡或 2016 年 12 月 31 日。父母的人格障碍根据《国际疾病分类》（ICD）第八版或第十版进行分类。采用泊松回归分析来估计后代（0-17 岁）中 ICD 第 10 版精神障碍的发病风险比（IRR）和累积发病率：研究队列包括 1 406 965 名儿童。对于女孩来说，母亲或父亲的人格障碍（MPD/PPD）与精神障碍有关：患有 MPD 的女孩（IRR，2.74；95% CI，2.59-2.89）和患有 PPD 的女孩（IRR，2.10；95% CI，1.94-2.27）。同样，多发性骨髓增生症男孩（IRR，2.44；95% CI，2.33-2.56）和多发性骨髓增生症男孩（IRR，2.04；95% CI，1.91-2.18）的风险也会增加。对于女孩和男孩而言，父母双方均患有人格障碍的风险最高（IRR，3.69；95% CI，3.15-4.33）。18 岁时，父母一方或双方患有人格障碍的儿童患任何精神障碍的累积发病率为 34.1%（95% CI，33.0-35.1），是未接触过人格障碍的儿童患精神障碍的累积发病率（15.2% [95% CI，15.1-15.3]）的两倍：结论：父母患有人格障碍的儿童患精神障碍的风险是未接触该疾病的儿童的 2 至 3.5 倍。父母将精神障碍遗传给子女的可能机制包括遗传、环境和基因-环境途径。有必要对这些机制进行更多的研究，并对预防性干预措施进行研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.