In vitro activity of delafloxacin against anaerobic bacteria compared with other antimicrobials

IF 2.5 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2023-12-23 DOI:10.1016/j.anaerobe.2023.102816

Fernando Cobo, Ana Franco-Acosta, Lina Martín-Hita, Javier Rodríguez-Granger, Antonio Sampedro-Martínez, Juan Antonio Reguera-Márquez, José María Navarro-Marí

引用次数: 0

Abstract

The aim of this study was to describe the in vitro activity of delafloxacin against 230 anaerobic isolates and compare it with the activity of other antimicrobials used against infections caused by anaerobic microorganisms. Minimal inhibitory concentrations (MICs) were lower for delafloxacin than for all other antibiotics tested with the exception of piperacillin-tazobactam and meropenem against Gram-positive anaerobic cocci. Only two (0.8 %) isolates of Bacteroides spp. showed a MIC ≥4 μg/mL. With some exceptions, the present results show lower MICs for delafloxacin in comparison to the other antibiotics used against anaerobes.

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与其他抗菌药相比，德拉氧氟沙星对厌氧菌的体外活性

本研究旨在描述德拉氧沙星对230株厌氧菌分离物的体外活性，并将其与其他用于治疗厌氧微生物感染的抗菌药的活性进行比较。除了哌拉西林-他唑巴坦和美罗培南之外，德拉氧沙星对革兰阳性厌氧球菌的最小抑菌浓度（MICs）低于所有其他受试抗生素。只有两例（0.8%）分离出的乳杆菌的 MIC 值≥4 μg/mL。除个别情况外，目前的结果显示，与其他用于厌氧菌的抗生素相比，德拉氧沙星的 MIC 值较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.