Preclinical pharmacokinetics and herb-drug interaction studies of atorvastatin co-administered with the herbal slimming products

IF 0.7 4区生物学 Q4 PLANT SCIENCES

Indian Journal of Traditional Knowledge Pub Date : 2023-12-13 DOI:10.56042/ijtk.v22i4.7196

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引用次数: 0

Abstract

Herbal slimming products (HSPs) contain multiple herbs used in weight loss. Phytoconstituents of several plant extracts show the inhibitory effects on the drug-metabolizing enzymes causing interaction when taken with other drugs. Atorvastatin (ATS) is used in the treatment of hyperlipidemia. This study aimed to investigate the effect of HSPs on the pharmacokinetics and pharmacodynamics of ATS. ATS (10 mg/Kg) was administered alone or in combination with HSP1 (200 mg/Kg)/ HSP2 (165 mg/Kg) orally in the SD rats for pharmacokinetics study. Hyperlipidemia was induced in Golden Syrian Hamster by feeding HFD (60% kcal). Furthermore, biochemical levels in serum, ROS, gene expression and lipid accumulation levels were examined in hamster liver tissue. HSPs have significantly enhanced the permeability and inhibited the metabolism of ATS by inhibiting the CYP3A4 isoenzyme confirmed by in vitro assay. Co-administration of HSPs with ATS enhanced the relative bioavailability of ATS.Concomitant administration of HSPs with ATS has significantly reduced the fat content, inflammatory cytokines, TG, VLDL, LDL levels, tissue MDA level, HMGCR and SREBP1c mRNA expression levels, lipid accumulation as well as collagen content and has increased the serum HDL level as well as tissue SOD, CAT, GHS and mRNA expression levels of LXRα and CYP7A1. The aforementioned outcomes indicated that coadministration of HSPs with ATS may lead to herb-drug interaction. Therefore, precaution should be taken and dose adjustment is required when administered simultaneously.

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阿托伐他汀与中药减肥产品联合用药的临床前药代动力学和中药-药物相互作用研究

草本减肥产品（HSPs）含有多种用于减肥的草药。几种植物提取物中的植物成分对药物代谢酶有抑制作用，与其他药物一起服用时会产生相互作用。阿托伐他汀（ATS）用于治疗高脂血症。本研究旨在探讨 HSPs 对 ATS 药代动力学和药效学的影响。在药代动力学研究中，给 SD 大鼠口服单独或与 HSP1（200 毫克/千克）/ HSP2（165 毫克/千克）联用的 ATS（10 毫克/千克）。金色叙利亚仓鼠通过喂食高纤维食物（60% 千卡）诱发高脂血症。此外，还检测了仓鼠肝组织中的血清生化水平、ROS、基因表达和脂质积累水平。体外试验证实，HSPs 通过抑制 CYP3A4 同工酶，明显增强了苯丙胺类兴奋剂的渗透性并抑制了其代谢。同时服用 HSPs 和苯丙胺类兴奋剂能明显降低脂肪含量、炎症细胞因子、总胆固醇、超低胆固醇、低密度脂蛋白水平、组织 MDA 水平、HMGCR 和 SREBP1c mRNA 表达水平、脂质积累以及胶原蛋白含量，并能提高血清高密度脂蛋白水平、组织 SOD、CAT、GHS 以及 LXRα 和 CYP7A1 的 mRNA 表达水平。上述结果表明，在服用苯丙胺类兴奋剂的同时服用 HSPs 可能会导致草药与药物之间的相互作用。因此，同时服用时应采取预防措施并调整剂量。

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来源期刊

Indian Journal of Traditional Knowledge 生物-植物科学

CiteScore

1.80

自引率

37.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Traditional knowledge" is employed to mean knowledge, innovations and practices of indigenous and local communities embodying traditional life-styles; the wisdom developed over many generations of holistic traditional scientific utilization of the lands, natural resources, and environment. It is generally passed down by word of mouth, from generation to generation and is, for the most part, undocumented. Traditional knowledge is valid and necessary, and awaits its currently relevant wider application for human benefit. National Institute of Science Communication and Information Resources, CSIR felt a need to document the recent developments and the information bygone in this area in the form of an interdisciplinary periodical. The Indian Journal of Traditional Knowledge will carry original research papers, review articles, short communications, etc. concerned with the observation and experimental investigation of the biological activities of the materials from plants, animals and minerals, used in the traditional health-care systems such as Ayurveda, Siddha, Yoga, Unani, Naturopathy, Homoeopathy, Folk-remedies, etc. As validation of indigenous claims it will cover Ethno-biology, Ethno-medicine, Ethno-pharmacology, Ethno-pharmacognosy & Clinical Studies on efficacy .