The effect of Nigella sativa on serum levels of insulin-like growth factor and its binding proteins in postmenopausal women with low bone density: A triple-blind randomized controlled trial

IF 0.7 4区生物学 Q4 PLANT SCIENCES

Indian Journal of Traditional Knowledge Pub Date : 2023-12-13 DOI:10.56042/ijtk.v22i4.7205

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引用次数: 0

Abstract

Animal studies have shown that Nigella sativa (NS) seed oil can increase Insulin-like growth factor (IGF-1) serum levels. This study aimed to investigate the effect of oral capsule NS on serum levels of IGF-1 and its binding proteins (IGFBP-1, IGFBP-3) in postmenopausal women with bone loss density. Sixty postmenopausal women of 50 to 65 years with bone loss density randomly received a soft capsule of NS oil 1000 mg or placebo once daily for six months with a 1:1 allocation ratio. DEXA method was used to measure bone density. Serum concentrations of IGF-1, IGFBP-1 and-3, ALT, AST, ALP, Cr, and urea were measured at baseline and after the intervention. There were no significant differences in serum levels of IGF1, IGFBP-1, urea, Cr, ALT, AST, and ALP between the two groups at the end of six months. However, a significant increase has been shown in IGFBP-3 between groups after the intervention (Adjusted mean difference: 95% CI: 1.65: 0.36 to 2.97; p=0.013). We observed a significant increase in IGFBP-3 serum levels without any side effects. Additional research with an increased number of participants may be needed for further clarification of its beneficial anabolic effects on the GH system.

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黑麦草对绝经后低骨密度妇女血清中胰岛素样生长因子及其结合蛋白水平的影响：三盲随机对照试验

动物实验表明，黑麦草籽油能提高血清中胰岛素样生长因子（IGF-1）的水平。本研究旨在探讨口服NS胶囊对骨密度下降的绝经后妇女血清中IGF-1及其结合蛋白（IGFBP-1、IGFBP-3）水平的影响。60 名 50 至 65 岁的绝经后骨质疏松妇女按 1:1 的分配比例随机接受每天一次 1000 毫克 NS 油软胶囊或安慰剂，为期 6 个月。采用 DEXA 法测量骨密度。在基线和干预后测量血清中 IGF-1、IGFBP-1 和 3、ALT、AST、ALP、Cr 和尿素的浓度。6 个月结束时，两组患者血清中的 IGF1、IGFBP-1、尿素、Cr、ALT、AST 和 ALP 水平无明显差异。然而，干预后，两组间的 IGFBP-3 有了明显增加（调整后的平均差：95% CI：1.65：0.36 至 2.97；P=0.013）。我们观察到 IGFBP-3 血清水平明显提高，且无任何副作用。为了进一步阐明 IGFBP-3 对 GH 系统有益的合成代谢作用，可能还需要进行更多的研究。

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来源期刊

Indian Journal of Traditional Knowledge 生物-植物科学

CiteScore

1.80

自引率

37.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Traditional knowledge" is employed to mean knowledge, innovations and practices of indigenous and local communities embodying traditional life-styles; the wisdom developed over many generations of holistic traditional scientific utilization of the lands, natural resources, and environment. It is generally passed down by word of mouth, from generation to generation and is, for the most part, undocumented. Traditional knowledge is valid and necessary, and awaits its currently relevant wider application for human benefit. National Institute of Science Communication and Information Resources, CSIR felt a need to document the recent developments and the information bygone in this area in the form of an interdisciplinary periodical. The Indian Journal of Traditional Knowledge will carry original research papers, review articles, short communications, etc. concerned with the observation and experimental investigation of the biological activities of the materials from plants, animals and minerals, used in the traditional health-care systems such as Ayurveda, Siddha, Yoga, Unani, Naturopathy, Homoeopathy, Folk-remedies, etc. As validation of indigenous claims it will cover Ethno-biology, Ethno-medicine, Ethno-pharmacology, Ethno-pharmacognosy & Clinical Studies on efficacy .