Novel FSH receptor heterodimer may be related to the high prolificacy of Jintang black goat

Ye Cao, Sujun Zhao, M. Chu, R. Di, Yufang Liu, Li Liu, Xueqin Zhang, Shaoping Qian, Yizheng Zhang
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Abstract

Follicle‐stimulating hormone (FSH) is the central hormone of the mammalian reproductive system. It targets the FSH receptor (FSHR), a member of the G protein‐coupled receptor family, to induce the FSH signal transduction. In the highly prolific Jintang black goat, gonadotropin level is not higher than that of Boer goat. However, two isoforms of FSHRs (FSHRA and FSHRB), generated from the alternative splicing of the same primary FSHR transcript, were expressed in the reproductive organs of Jintang black goat simultaneously. The mRNA level of FSHRB is 45.89, 3.80, and 13.81 times greater than that of FSHRA in the hypothalamus, pituitary, and ovary of the Jintang black goat, respectively. We found that FSHRA could interact with FSHRB protein, leading to augment of the FSH signaling transduction pathway. The enhancement of FSH signaling could increase the in vitro oocyte maturation rate. It implied that this might be the important reason for the high prolificacy in Jintang black goat.
新型 FSH 受体异二聚体可能与金堂黑山羊的高产有关
促卵泡激素(FSH)是哺乳动物生殖系统的核心激素。它以G蛋白偶联受体家族的FSH受体(FSHR)为靶标,诱导FSH信号转导。高产的金堂黑山羊的促性腺激素水平并不比波尔山羊高。然而,在金堂黑山羊的生殖器官中同时表达了两种FSHR异构体(FSHRA和FSHRB),这两种异构体是由相同的FSHR主转录本的替代剪接产生的。在金堂黑山羊的下丘脑、垂体和卵巢中,FSHRB的mRNA水平分别是FSHRA的45.89倍、3.80倍和13.81倍。我们发现,FSHRA能与FSHRB蛋白相互作用,导致FSH信号转导通路的增强。FSH信号转导通路的增强可提高体外卵母细胞成熟率。这意味着这可能是金堂黑山羊高产的重要原因。
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