Evaluation of role of Jasminum sambac against ulcerative colitis in rats

IF 0.7 4区生物学 Q4 PLANT SCIENCES

Indian Journal of Traditional Knowledge Pub Date : 2023-12-13 DOI:10.56042/ijtk.v22i4.7199

{"title":"Evaluation of role of Jasminum sambac against ulcerative colitis in rats","authors":"","doi":"10.56042/ijtk.v22i4.7199","DOIUrl":null,"url":null,"abstract":"Current investigation is designed to find out the role of Jasminum sambac (JS) against Acetic Acid (AA)-induced ulcerative colitis in rats. 30 male albino Wistar rats were randomly separated into 5 batches (n=6): normal: admitted with distilled water for 7 days; negative: received the distilled water for 1- 3 days and from 4-7 days received the 2 mL of AA (4% v/v) rectally; test 1, 2 and standard group: orally received the ethanolic extract of leaves of Jasminum sambac (EEJS) at doses 250, 500 mg/kg and prednisolone 2 mg/kg from 1-3 days without AA and from 4-7 days received the 2 mL of 4% v/v AA rectally after 2 h administration of EEJS and prednisolone. On 8th day rats were sacrificed and colon tissues were examined. Rats with acetic acid-induced colitis exhibited significant decrease in body weight, colon length, superoxide dismutase, catalase, reduced glutathione, significant rise in colon weight, oedema, disease activity index, macroscopic damage score, occult blood in stool, stool consistency and lipid peroxidation. Pre-treatment with EEJS at doses 250, 500 mg/kg orally significantly regularized the above-mentioned parameters in dose dependent manner. Ethanolic extract of Jasminum sambac could protect the AA-produced ulcerative colitis by attenuation of macroscopic damage, microscopic damage, and oxidative biomarkers.","PeriodicalId":56294,"journal":{"name":"Indian Journal of Traditional Knowledge","volume":"69 6","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Traditional Knowledge","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.56042/ijtk.v22i4.7199","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PLANT SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Current investigation is designed to find out the role of Jasminum sambac (JS) against Acetic Acid (AA)-induced ulcerative colitis in rats. 30 male albino Wistar rats were randomly separated into 5 batches (n=6): normal: admitted with distilled water for 7 days; negative: received the distilled water for 1- 3 days and from 4-7 days received the 2 mL of AA (4% v/v) rectally; test 1, 2 and standard group: orally received the ethanolic extract of leaves of Jasminum sambac (EEJS) at doses 250, 500 mg/kg and prednisolone 2 mg/kg from 1-3 days without AA and from 4-7 days received the 2 mL of 4% v/v AA rectally after 2 h administration of EEJS and prednisolone. On 8th day rats were sacrificed and colon tissues were examined. Rats with acetic acid-induced colitis exhibited significant decrease in body weight, colon length, superoxide dismutase, catalase, reduced glutathione, significant rise in colon weight, oedema, disease activity index, macroscopic damage score, occult blood in stool, stool consistency and lipid peroxidation. Pre-treatment with EEJS at doses 250, 500 mg/kg orally significantly regularized the above-mentioned parameters in dose dependent manner. Ethanolic extract of Jasminum sambac could protect the AA-produced ulcerative colitis by attenuation of macroscopic damage, microscopic damage, and oxidative biomarkers.

查看原文本刊更多论文

评估茉莉花对大鼠溃疡性结肠炎的作用

目前的研究旨在找出茉莉花（Jasminum sambac，JS）对醋酸（AA）诱导的大鼠溃疡性结肠炎的作用。将 30 只雄性白化 Wistar 大鼠随机分为 5 组（n=6）：正常组：用蒸馏水喂养 7 天；阴性组：用蒸馏水喂养 1-3 天，4-7 天后直肠注射 2 mL AA（4% v/v）；试验 1、2 和标准组：试验 1、2 和标准组：1-3 天口服剂量为 250、500 毫克/千克的茉莉叶乙醇提取物（EEJS）和 2 毫克/千克的泼尼松龙，不含 AA，4-7 天在服用 EEJS 和泼尼松龙 2 小时后直肠注射 2 毫升 4% v/v AA。第 8 天，大鼠被处死并对结肠组织进行检查。醋酸诱导的结肠炎大鼠的体重、结肠长度、超氧化物歧化酶、过氧化氢酶、还原型谷胱甘肽显著下降，结肠重量、水肿、疾病活动指数、宏观损伤评分、隐血便、粪便稠度和脂质过氧化物显著增加。口服剂量为 250、500 毫克/千克的 EEJS 可显著改善上述参数，且与剂量相关。茉莉花乙醇提取物可通过减轻宏观损伤、微观损伤和氧化生物标志物来保护 AA 引起的溃疡性结肠炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Indian Journal of Traditional Knowledge 生物-植物科学

CiteScore

1.80

自引率

37.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Traditional knowledge" is employed to mean knowledge, innovations and practices of indigenous and local communities embodying traditional life-styles; the wisdom developed over many generations of holistic traditional scientific utilization of the lands, natural resources, and environment. It is generally passed down by word of mouth, from generation to generation and is, for the most part, undocumented. Traditional knowledge is valid and necessary, and awaits its currently relevant wider application for human benefit. National Institute of Science Communication and Information Resources, CSIR felt a need to document the recent developments and the information bygone in this area in the form of an interdisciplinary periodical. The Indian Journal of Traditional Knowledge will carry original research papers, review articles, short communications, etc. concerned with the observation and experimental investigation of the biological activities of the materials from plants, animals and minerals, used in the traditional health-care systems such as Ayurveda, Siddha, Yoga, Unani, Naturopathy, Homoeopathy, Folk-remedies, etc. As validation of indigenous claims it will cover Ethno-biology, Ethno-medicine, Ethno-pharmacology, Ethno-pharmacognosy & Clinical Studies on efficacy .