Application of a new, simple method for quantitative collection of 24-hour urines in small laboratory animals: determination of basal excretion of proteins, creatinine, urea, electrolytes, and of free steroids.
{"title":"Application of a new, simple method for quantitative collection of 24-hour urines in small laboratory animals: determination of basal excretion of proteins, creatinine, urea, electrolytes, and of free steroids.","authors":"M Fenske","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The application of a simple method for collection of 24-hour urines in laboratory animals is described and basal excretion values of urinary proteins, creatinine, urea, electrolytes and of free steroids (glucocorticosteroids, DHEA, progesterone, testosterone) in small laboratory animals like the Mongolian gerbil, rat, guinea pig and tree shrew were measured. The major advantage of this method is that cages are identical in size to animal's home cages, are easily constructed and cheap, and that dried and liquid portions of each 24-hour urine are quantitatively removed from aluminium sheets by a simple washing step. This facilitates the monitoring of changes of urinary excretion rates over longer time periods without stressing the animals by handling.</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"32 2","pages":"65-70"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Versuchstierkunde","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The application of a simple method for collection of 24-hour urines in laboratory animals is described and basal excretion values of urinary proteins, creatinine, urea, electrolytes and of free steroids (glucocorticosteroids, DHEA, progesterone, testosterone) in small laboratory animals like the Mongolian gerbil, rat, guinea pig and tree shrew were measured. The major advantage of this method is that cages are identical in size to animal's home cages, are easily constructed and cheap, and that dried and liquid portions of each 24-hour urine are quantitatively removed from aluminium sheets by a simple washing step. This facilitates the monitoring of changes of urinary excretion rates over longer time periods without stressing the animals by handling.
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