Unusual sites of giant cell tumor of bone

Abstract

Giant cell tumor (GCT), a benign but regionally aggressive and destructive tumor, is most frequently found at the epiphysis of long bones. The distal femur, proximal tibia, and distal radius are the three most typical locations. The pelvis, proximal femur, proximal humerus, distal tibia, and sacrum are uncommon locations. About 18– 23% of benign bone neoplasms are GCT. They often manifest in early adulthood because they happen after the growth plate has closed, with the majority of instances being documented between the ages of 20 and 50. GCT is a primarily benign bone tumor that exhibits local recurrence, has metastasis potential, and may show malignant change. Depending on the site, complications such as hemorrhage or pathological fracture, GCTs can have varied appearances. Rarely, ribs, vertebral bodies, and bones of the hand and foot may be affected. Other than the long bones, the radiographic characteristics of GCT are non-specific and resemble those of other osteolytic diseases. This review shows GCT imaging features from both typical and unusual locales.