Moisturizers for treatment and prophylaxis of atopic dermatitis exacerbations

Abstract

Atopic dermatitis (AD) is a global problem with increasing prevalence rates worldwide. Genetic predisposition to allergies, epidermal barrier dysfunction, and T2 immune response, underlies AD. Xerosis, itchy skin and exacerbation are the main AD symptoms, leading to increased permeability of allergens and microbes through the damaged epidermis and to the development of sensitization. The main purpose of AD therapy is to achieve long-term remission and to improve quality of life. Topical treatment includes glucocorticosteroids, topical calcineurin inhibitors and emollients for reducing inflammation, xerosis and prevention of infection. Daily use of effective emollients as basic skin care can improve epidermal barrier function, provide hydration of the skin end reduce the topical glucocorticosteroids needs.