Preparation of hexagonal boron nitride polymer systems with one-step sol–gel synthesis for pH-controlled drug delivery

IF 2.8 4区工程技术 Q2 POLYMER SCIENCE

Macromolecular Research Pub Date : 2023-12-21 DOI:10.1007/s13233-023-00231-9

Fatih Ozcan, Esra Maltas Cagil

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Abstract

In this work, new pH-sensitive hexagonal boron nitride–polysaccharides nanosystems were produced using sol–gel method. These hybrid sol–gel systems include β-cyclodextrin (β-CD), dextrin (Dex), shellac wax (Wax), and polyethylene glycol which were synthesized with hexagonal boron nitride (h-BN) by coupling of triethyl orthosilicate and donepezil. The release studies of DNP from each sol–gel systems were studied using buffers at various pH levels such as 2.2, 4.0, 6.0, 7.4, and 8.6. The release percentages of the drug were calculated by regression equations of the DNP which has maximum fluorescence intensity at 325 and 387 nm excitation and emission wavelengths. These new sol–gel hexagonal boron nitride systems were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, and scanning electron microscopy analysis. According to the results. The sol–gel systems with polysaccharide-based dextrin (h-BN–Dex) and shellac wax (h-BN–Wax) were more available at a pH levels of 6, 7.4, and 8.6 for the release of DNP.

Graphical abstract

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用一步溶胶-凝胶合成法制备六方氮化硼聚合物体系，用于 pH 值控制的药物输送

本研究采用溶胶-凝胶法制备了新型 pH 敏感的六方氮化硼-多糖纳米体系。这些混合溶胶-凝胶体系包括β-环糊精（β-CD）、糊精（Dex）、虫胶蜡（Wax）和聚乙二醇。使用不同 pH 值（如 2.2、4.0、6.0、7.4 和 8.6）的缓冲液对每种溶胶-凝胶体系中 DNP 的释放进行了研究。DNP 在 325 和 387 nm 波长的激发和发射波长处具有最大荧光强度，通过回归方程计算出药物的释放百分比。傅立叶变换红外光谱、透射电子显微镜和扫描电子显微镜分析对这些新型溶胶凝胶六方氮化硼系统进行了表征。结果显示含有多糖糊精（h-BN-Dex）和虫胶蜡（h-BN-Wax）的溶胶凝胶体系在 pH 值为 6、7.4 和 8.6 时更容易释放 DNP。

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来源期刊

Macromolecular Research 工程技术-高分子科学

CiteScore

4.70

自引率

8.30%

发文量

100

审稿时长

1.3 months

期刊介绍： Original research on all aspects of polymer science, engineering and technology, including nanotechnology Presents original research articles on all aspects of polymer science, engineering and technology Coverage extends to such topics as nanotechnology, biotechnology and information technology The English-language journal of the Polymer Society of Korea Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.