Stabilization of infant formulas against lipid oxidation: What are the key structural levers?

IF 1.8 3区农林科学 Q3 FOOD SCIENCE & TECHNOLOGY

European Journal of Lipid Science and Technology Pub Date : 2023-12-21 DOI:10.1002/ejlt.202300161

Mathilde Cancalon, Nathalie Barouh, Youna Hemery, Bruno Baréa, Erwann Durand, Claire Bourlieu-Lacanal, Pierre Villeneuve

{"title":"Stabilization of infant formulas against lipid oxidation: What are the key structural levers?","authors":"Mathilde Cancalon, Nathalie Barouh, Youna Hemery, Bruno Baréa, Erwann Durand, Claire Bourlieu-Lacanal, Pierre Villeneuve","doi":"10.1002/ejlt.202300161","DOIUrl":null,"url":null,"abstract":"Infant follow-on formulas (IFF) mimic human milk. This study aimed to identify the key structural levers that influence oxidative stability of IFF. Representative model IFF of marketed products in term of lipid composition were formulated with varying droplet size, lipid droplet core composition, and interfacial composition using different emulsifiers (soy lecithin or dairy phospholipids [DPL]). The oxidative stability of model IFF was assessed in accelerated storage conditions. No significant stabilization effect based on the lipid droplet core composition was observed. However, the nature of the interface, influenced by the emulsifier type, had an impact. Model IFF with DPL showed no loss of tocopherols and peroxide value was up to twice lower than those with soy lecithin after 20 days. This effect was particularly pronounced for the 0.4µm droplets. These results suggest that model IFF with DPL had a greater oxidative stability, likely due to the presence of sphingomyelin and the formation of a rigidified domain at the droplet surface. Model IFF with 0.4 µm droplets stabilized with soy lecithin, especially when added to the water phase, showed a tocopherols loss twice as high as that of IFF with DPL. These results indicate that oxidative stability of IFF is more influenced by the chemical environment rather than droplet size.Practical Application: Infant follow-on formulas (IFF) aim to ensure an adequate nutritional intake to support the proper development and infant growth. Therefore, IFF must be stable against degradation phenomena such as lipid oxidation and have a composition and structure that are as biomimetic as possible to mature breast milk. This study provides key information for the development of IFF with a lipid composition and structure that are suitable for the infant nutritional needs and have an acceptable resistance to lipid oxidation. More generally, these results can be applied to all dispersed systems in the form of oil-in-water emulsions with a similar composition.","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejlt.202300161","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Lipid Science and Technology","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ejlt.202300161","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Infant follow-on formulas (IFF) mimic human milk. This study aimed to identify the key structural levers that influence oxidative stability of IFF. Representative model IFF of marketed products in term of lipid composition were formulated with varying droplet size, lipid droplet core composition, and interfacial composition using different emulsifiers (soy lecithin or dairy phospholipids [DPL]). The oxidative stability of model IFF was assessed in accelerated storage conditions. No significant stabilization effect based on the lipid droplet core composition was observed. However, the nature of the interface, influenced by the emulsifier type, had an impact. Model IFF with DPL showed no loss of tocopherols and peroxide value was up to twice lower than those with soy lecithin after 20 days. This effect was particularly pronounced for the 0.4µm droplets. These results suggest that model IFF with DPL had a greater oxidative stability, likely due to the presence of sphingomyelin and the formation of a rigidified domain at the droplet surface. Model IFF with 0.4 µm droplets stabilized with soy lecithin, especially when added to the water phase, showed a tocopherols loss twice as high as that of IFF with DPL. These results indicate that oxidative stability of IFF is more influenced by the chemical environment rather than droplet size.

Practical Application: Infant follow-on formulas (IFF) aim to ensure an adequate nutritional intake to support the proper development and infant growth. Therefore, IFF must be stable against degradation phenomena such as lipid oxidation and have a composition and structure that are as biomimetic as possible to mature breast milk. This study provides key information for the development of IFF with a lipid composition and structure that are suitable for the infant nutritional needs and have an acceptable resistance to lipid oxidation. More generally, these results can be applied to all dispersed systems in the form of oil-in-water emulsions with a similar composition.

Abstract Image

查看原文本刊更多论文

稳定婴儿配方奶粉，防止脂质氧化：关键的结构杠杆是什么？

婴儿配方奶粉（IFF）模拟母乳。本研究旨在找出影响 IFF 氧化稳定性的关键结构杠杆。使用不同的乳化剂（大豆卵磷脂或乳类磷脂 [DPL]）配制了不同液滴大小、脂滴核心成分和界面成分的具有代表性的市售产品脂质成分模型 IFF。在加速储存条件下，对模型 IFF 的氧化稳定性进行了评估。没有观察到基于脂滴核心成分的明显稳定效果。不过，界面的性质会受到乳化剂类型的影响。使用 DPL 的模型 IFF 在 20 天后生育酚没有损失，过氧化值比使用大豆卵磷脂的模型 IFF 低两倍。这种影响在 0.4 微米的液滴中尤为明显。这些结果表明，含有 DPL 的模型 IFF 具有更高的氧化稳定性，这可能是由于鞘磷脂的存在和液滴表面刚性结构域的形成。使用大豆卵磷脂稳定 0.4 µm 液滴的模型 IFF（尤其是加入水相时）显示的生育酚损失是使用 DPL 的 IFF 的两倍。这些结果表明，IFF 的氧化稳定性更多地受到化学环境而非液滴大小的影响：婴儿配方奶粉（IFF）旨在确保婴儿摄入充足的营养，以支持婴儿的正常发育和成长。因此，婴儿配方奶粉必须具有防止脂质氧化等降解现象的稳定性，其成分和结构应尽可能与成熟母乳相似。这项研究为开发具有适合婴儿营养需求的脂质成分和结构，并具有可接受的抗脂质氧化能力的 IFF 提供了关键信息。更广泛地说，这些结果可应用于具有类似成分的水包油乳剂形式的所有分散体系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Journal of Lipid Science and Technology 工程技术-食品科技

CiteScore

5.50

自引率

0.00%

发文量

101

审稿时长

6-16 weeks

期刊介绍： The European Journal of Lipid Science and Technology is a peer-reviewed journal publishing original research articles, reviews, and other contributions on lipid related topics in food science and technology, biomedical science including clinical and pre-clinical research, nutrition, animal science, plant and microbial lipids, (bio)chemistry, oleochemistry, biotechnology, processing, physical chemistry, and analytics including lipidomics. A major focus of the journal is the synthesis of health related topics with applied aspects. Following is a selection of subject areas which are of special interest to EJLST: Animal and plant products for healthier foods including strategic feeding and transgenic crops Authentication and analysis of foods for ensuring food quality and safety Bioavailability of PUFA and other nutrients Dietary lipids and minor compounds, their specific roles in food products and in nutrition Food technology and processing for safer and healthier products Functional foods and nutraceuticals Lipidomics Lipid structuring and formulations Oleochemistry, lipid-derived polymers and biomaterials Processes using lipid-modifying enzymes The scope is not restricted to these areas. Submissions on topics at the interface of basic research and applications are strongly encouraged. The journal is the official organ the European Federation for the Science and Technology of Lipids (Euro Fed Lipid).