To study magnetic resonance imaging findings and inflammatory markers in inflammatory sacroiliitis

Abstract

The objectives of the study are to determine magnetic resonance imaging (MRI) findings in inflammatory sacroiliitis and assign scores and grades to it and to determine and correlate erythrocyte sedimentation rate, C-reactive protein (CRP), and human leukocyte antigen-B27 (HLA-B27) in various grades of sacroiliitis. An observational cross-sectional study was conducted on 30 patients who clinically presented with features of sacroiliitis and underwent an MRI of sacroiliac joint (SIJ). Various inflammatory and structural findings on MRI were used to do Spondyloarthritis Research Consortium of Canada scoring and grading. Then inflammatory markers including erythrocyte sedimentation rate, CRP, and HLA-B27 were studied in various grades of sacroiliitis. Inflammatory sacroiliitis affects commonly the age group of 21–40 years. Periarticular edema was the most common finding seen with the iliac aspect more commonly involved. The majority of the subjects were graded moderate (50%). Values of erythrocyte sedimentation rate and CRP levels were raised whereas HLA-B27 was positive in 9 patients (30%) of inflammatory sacroiliitis. Inflammatory sacroiliitis presents with a chief complaint of low back ache. MRI helps to grade it into mild, moderate, and severe. STIR is the most sensitive sequence for the detection of bone marrow edema with bilateral symmetrical involvement but the iliac bone of SIJ is more involved than the sacral side. Contrast-enhanced sequences and diffusion images add no significant statistical role in the diagnosis of bone marrow edema. Inflammatory laboratory parameters were increased in higher grades of sacroiliitis. HLA-B27, although not specific to inflammatory sacroiliitis, increases in higher grades of sacroiliitis.