White matter hyperintensity predicts independent walking function at 6 months after stroke: A retrospective cohort study

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

NeuroRehabilitation Pub Date : 2023-12-22 DOI:10.3233/nre-230225

Masahiro Nomoto, Kazuhiro Miyata, Yutaka Kohno

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引用次数: 0

Abstract

BACKGROUND: White matter hyperintensity (WMH) is reported to have a potential prevalence in healthy people and is a predictor of walking disability. However, WMH has not been adequately considered as a predictor of independent walking after stroke. OBJECTIVE: To investigate the effects of WMH severity on walking function in patients with acute stroke. METHODS: The retrospective cohort study included 422 patients with acute stroke. The WMH severity from magnetic resonance images was evaluated using the Fazekas scale. Age, type of stroke, Fazekas scale, Brunnstrom motor recovery stage, Motricity Index, and Mini-Mental State Examination were used as independent variables. Multivariable logistic regression analysis was conducted on the factors of independent walking at discharge and 6 months after onset, respectively. RESULTS: Multivariable analysis revealed that the Fazekas scale is not a predictive factor of independent walking at discharge (odds ratio [OR] = 0.89, 95% confidence intervals [CI] = 0.65–1.22), but at 6 months (OR = 0.54, 95% CI = 0.34–0.86). CONCLUSION: The WMH severity was a predictive factor of independent walking in patients with acute stroke after 6 months. WMH is a factor that should be considered to improve the accuracy of predicting long-term walking function in patients with stroke.

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白质高密度可预测中风后 6 个月的独立行走功能：回顾性队列研究

背景：据报道，白质高密度（WMH）在健康人中具有潜在的患病率，并且是预测行走残疾的一个指标。然而，WMH 作为卒中后独立行走的预测指标尚未得到充分考虑。目的：研究 WMH 严重程度对急性卒中患者行走功能的影响。方法：该回顾性队列研究纳入了 422 名急性卒中患者。使用 Fazekas 量表对磁共振图像中的 WMH 严重程度进行评估。将年龄、中风类型、Fazekas 量表、Brunnstrom 运动恢复阶段、运动指数和迷你精神状态检查作为自变量。分别对出院时和发病 6 个月后独立行走的因素进行了多变量逻辑回归分析。结果：多变量分析表明，法泽卡斯量表不是出院时独立行走的预测因素（几率比[OR] = 0.89，95% 置信区间[CI] = 0.65-1.22），但在 6 个月时（OR = 0.54，95% CI = 0.34-0.86）却是独立行走的预测因素。结论：WMH 严重程度是急性卒中患者 6 个月后独立行走的预测因素。为了提高预测脑卒中患者长期行走功能的准确性，应考虑 WMH 这一因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroRehabilitation CLINICAL NEUROLOGY-REHABILITATION

CiteScore

3.20

自引率

0.00%

发文量

178

审稿时长

6-12 weeks

期刊介绍： NeuroRehabilitation, an international, interdisciplinary, peer-reviewed journal, publishes manuscripts focused on scientifically based, practical information relevant to all aspects of neurologic rehabilitation. We publish unsolicited papers detailing original work/research that covers the full life span and range of neurological disabilities including stroke, spinal cord injury, traumatic brain injury, neuromuscular disease and other neurological disorders. We also publish thematically organized issues that focus on specific clinical disorders, types of therapy and age groups. Proposals for thematic issues and suggestions for issue editors are welcomed.