Modeling nontuberculous mycobacterial infections in zebrafish.

IF 14 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Trends in Microbiology Pub Date : 2024-07-01 Epub Date: 2023-12-21 DOI:10.1016/j.tim.2023.11.011
Matt D Johansen, Herman P Spaink, Stefan H Oehlers, Laurent Kremer
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引用次数: 0

Abstract

The incidence of infections due to nontuberculous mycobacteria (NTM) has increased rapidly in recent years, surpassing tuberculosis in developed countries. Due to inherent antimicrobial resistance, NTM infections are particularly difficult to treat with low cure rates. There is an urgent need to understand NTM pathogenesis and to develop novel therapeutic approaches for the treatment of NTM diseases. Zebrafish have emerged as an excellent animal model due to genetic amenability and optical transparency during embryonic development, allowing spatiotemporal visualization of host-pathogen interactions. Furthermore, adult zebrafish possess fully functional innate and adaptive immunity and recapitulate important pathophysiological hallmarks of mycobacterial infection. Here, we report recent breakthroughs in understanding the hallmarks of NTM infections using the zebrafish model.

在斑马鱼中模拟非结核分枝杆菌感染。
近年来,非结核分枝杆菌(NTM)感染的发病率迅速上升,在发达国家已超过结核病。由于固有的抗菌药耐药性,NTM 感染尤其难以治疗,治愈率很低。目前迫切需要了解非淋菌性结核病的发病机制,并开发治疗非淋菌性结核病的新型疗法。斑马鱼在胚胎发育过程中具有遗传适应性和光学透明性,可对宿主与病原体之间的相互作用进行时空可视化,因此已成为一种极佳的动物模型。此外,成年斑马鱼具有功能完备的先天性和适应性免疫,并能再现分枝杆菌感染的重要病理生理特征。在此,我们报告了利用斑马鱼模型了解非典型肺炎感染特征的最新突破。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Microbiology
Trends in Microbiology 生物-生化与分子生物学
CiteScore
25.30
自引率
0.60%
发文量
193
审稿时长
6-12 weeks
期刊介绍: Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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