Sebastian Proschinger, Alexander Schenk, Alan J Metcalfe, Philipp Zimmer
{"title":"HIIT Induces Stronger Shifts within the Peripheral T Cell Compartment Independent of Sex.","authors":"Sebastian Proschinger, Alexander Schenk, Alan J Metcalfe, Philipp Zimmer","doi":"10.1055/a-2197-0882","DOIUrl":null,"url":null,"abstract":"<p><p>Acute exercise induces changes within the T-cell compartment, especially in cytotoxic CD8<sup>+ </sup>memory subsets, depending on exercise intensity and duration. It is unclear whether exercise-induced changes in major T-cell subsets differ in response to acute high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) and whether sex-specific effects exist. Twenty-four recreationally active runners (females: n=12, 27.8±4.1years, 54.4±4.6 ml*kg<sup>-1</sup>*min<sup>-1</sup>; males: n=12, 31.6±3.8years, 58.9±7.7 ml*kg<sup>-1</sup>*min<sup>-1</sup>) participated in this randomized controlled crossover study, and conducted an energy- and duration-matched HIIT and MICT session. Blood was sampled before (T<sub>1</sub>), immediately (T<sub>2</sub>) and 1 h after exercise (T<sub>3</sub>). Flow cytometry was used to identify T-cell populations. HIIT decreased the proportion of CD8<sup>+ </sup>T-cells more pronounced at T<sub>3</sub> compared to MICT (p=0.007), induced a significantly stronger increase in the CD8<sup>+ </sup>effector memory (T<sub>EM</sub>) cell proportion at T<sub>2</sub> (p=0.032), and decreased CD4<sup>+ </sup>central memory proportion more pronounced at T<sub>2</sub> (p=0.029). A decrease below baseline CD8<sup>+ </sup>T<sub>EM</sub> proportion at T<sub>3</sub> was observed only after HIIT (p<0.001). No interaction effects between sexes were revealed. Taken together, HIIT represents a more potent stimulus to induce shifts mainly within the cytotoxic CD8<sup>+ </sup>T-cell compartment, thereby giving implications to investigate the role of HIIT on the cell´s effector phenotype and function in more detail.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of sports medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/a-2197-0882","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/22 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"SPORT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Acute exercise induces changes within the T-cell compartment, especially in cytotoxic CD8+ memory subsets, depending on exercise intensity and duration. It is unclear whether exercise-induced changes in major T-cell subsets differ in response to acute high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) and whether sex-specific effects exist. Twenty-four recreationally active runners (females: n=12, 27.8±4.1years, 54.4±4.6 ml*kg-1*min-1; males: n=12, 31.6±3.8years, 58.9±7.7 ml*kg-1*min-1) participated in this randomized controlled crossover study, and conducted an energy- and duration-matched HIIT and MICT session. Blood was sampled before (T1), immediately (T2) and 1 h after exercise (T3). Flow cytometry was used to identify T-cell populations. HIIT decreased the proportion of CD8+ T-cells more pronounced at T3 compared to MICT (p=0.007), induced a significantly stronger increase in the CD8+ effector memory (TEM) cell proportion at T2 (p=0.032), and decreased CD4+ central memory proportion more pronounced at T2 (p=0.029). A decrease below baseline CD8+ TEM proportion at T3 was observed only after HIIT (p<0.001). No interaction effects between sexes were revealed. Taken together, HIIT represents a more potent stimulus to induce shifts mainly within the cytotoxic CD8+ T-cell compartment, thereby giving implications to investigate the role of HIIT on the cell´s effector phenotype and function in more detail.
期刊介绍:
The IJSM provides a forum for the publication of papers dealing with both basic and applied information that advance the field of sports medicine and exercise science, and offer a better understanding of biomedicine. The journal publishes original papers, reviews, short communications, and letters to the Editors.