Does leptin cause proximal gastric cancer in the obese? The role of serum leptin in the etiology of proximal gastric cancer.

IF 1.1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-12-25 eCollection Date: 2023-12-01 DOI:10.1515/hmbci-2022-0101

Tomaz Jagric, Gaja Hladnik, Rok Kolaric, Marjeta Dugonik, Evgenija Homsak

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引用次数: 0

Abstract

Objectives: The aim of the present study was to determine the correlation between obesity, serum levels of leptin and proximal gastric cancer.

Methods: Sixty-four gastric cancer patients operated on with curative intent were included in the study. We determined the correlation between the preoperative serum levels of leptin and the tumor's location.

Results: Serum leptin levels were correlated significantly with the proximal third location (p=0.04), gastric outlet obstructing tumors (p<0.0001), CRP levels (p=0.03) and BMI (p<0.0001). Patients with high serum levels of leptin had significantly more intestinal types of gastric cancer (p=0.033) and better differentiation (p=0.009). The linear regression model determined the proximal tumor location (beta: 0.467; p=0.045), BMI (beta: 0.657; p=0.001), high preoperative serum albumin (beta: 0.563; p=0.016) and the presence of pyloric stenosis (beta: 0.525; p=0.006) as related significantly to serum leptin levels. The Cox proportional hazard model identified age (HR: 0.003; 95 % CI: 0-0.794; p=0.041), preoperative serum levels of leptin (HR: 0.125; 95 % CI: 0.018-0.887; p=0.037) and the number of extracted LNs (HR: 0.001; 95 % CI: 0-0.677; p=0.038) as independent prognostic factors.

Conclusions: Serum levels of leptin were significantly elevated in patients with proximal gastric cancer, suggesting that the leptin's effect might be due to its systemic secretion. This might explain the higher incidence of proximal gastric cancer in obese patients. Elevated serum leptin levels were an independent prognostic factor.

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瘦素会导致肥胖者患近端胃癌吗？血清瘦素在近端胃癌病因学中的作用。

目的：本研究旨在确定肥胖、血清瘦素水平与近端胃癌之间的相关性：本研究旨在确定肥胖、血清瘦素水平与近端胃癌之间的相关性：研究纳入了 64 名接受根治性手术的胃癌患者。我们测定了术前血清瘦素水平与肿瘤位置之间的相关性：结果：血清瘦素水平与肿瘤近端第三位置（P=0.04）、胃出口梗阻性肿瘤（P结论：血清瘦素水平与肿瘤近端第三位置（P=0.04）、胃出口梗阻性肿瘤（P=0.04）显著相关：近端胃癌患者的血清瘦素水平明显升高，表明瘦素的作用可能是由于其全身性分泌。这可能是肥胖患者近端胃癌发病率较高的原因。血清瘦素水平升高是一个独立的预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.