Acute vapour inhalation toxicity of acrolein and its influence as a trace contaminant in 2-methoxy-3,4-dihydro-2H-pyran.

Human toxicology Pub Date : 1989-05-01 DOI:10.1177/096032718900800305

B Ballantyne, D E Dodd, I M Pritts, D J Nachreiner, E H Fowler

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引用次数: 15

Abstract

1. The LC50 values for acrolein (AC) vapour to Sprague-Dawley rats (combined sexes) were determined to be 26 ppm (1 h) and 8.3 ppm (4 h). Signs of severe irritancy were present, and death was due to lung injury. 2. Exposure of rats to a 2-methoxy-3,4-dihydro-2H-pyran (MDP) saturated vapour atmosphere statistically generated from liquid MDP containing 0.037% AC, caused severe irritancy and death from accumulation of AC vapour. Sparging the impure material with nitrogen gas before atmosphere generation significantly reduced or abolished lethal toxicity. 3. Dynamically generated MDP vapour atmosphere produced transient respiratory and ocular irritancy, but no mortalities. The intrinsic acute vapour inhalation toxicity of MDP is low. 4. The presence of highly volatile toxic impurities in a material may confer a significant acute inhalation toxicity and hazard under conditions of low air movement. Assessment of potential inhalation hazards from liquid mixtures may require investigation by static and dynamic methods for vapour generation.

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丙烯醛作为2-甲氧基-3,4-二氢- 2h -吡喃中微量污染物的急性蒸气吸入毒性及其影响。

1. 丙烯醛(AC)蒸气对Sprague-Dawley大鼠(两性)的LC50值分别为26 ppm (1 h)和8.3 ppm (4 h)。存在严重刺激的迹象，并因肺损伤而死亡。2. 将大鼠暴露于含有0.037% AC的液态MDP产生的2-甲氧基-3,4-二氢- 2h -吡喃(MDP)饱和蒸气气氛中，会引起严重的刺激和因AC蒸气积累而死亡。在产生大气之前用氮气喷淋不纯物质可显著降低或消除致命毒性。3.动态产生的MDP蒸汽大气产生短暂的呼吸和眼部刺激，但无死亡。MDP固有的急性蒸汽吸入毒性较低。4. 在低空气流动条件下，材料中存在高挥发性有毒杂质可能会产生严重的急性吸入毒性和危害。评估液体混合物的潜在吸入危害可能需要对蒸汽产生的静态和动态方法进行调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Human toxicology

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