Microbiota Composition and Probiotics Supplementations on Sleep Quality-A Systematic Review and Meta-Analysis.

IF 2.1 Q3 CLINICAL NEUROLOGY
Daniele Santi, Valentina Debbi, Francesco Costantino, Giorgia Spaggiari, Manuela Simoni, Carla Greco, Livio Casarini
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Abstract

The gut microbiota (GM) plays a crucial role in human health. The bidirectional interaction between GM and the central nervous system may occur via the microbiota-gut-brain axis, possibly regulating the sleep/wake cycle. Recent reports highlight associations between intestinal dysbiosis and sleep disorders, suggesting that probiotics could ameliorate this condition. However, data are poor and inconsistent. The aim of this quantitative metanalytic study is to assess the GM composition in sleep disturbances and evaluate probiotics' effectiveness for managing sleep disorders. A systematic review was carried out until July 2022 in online databases, limiting the literature research to human studies and English language articles. No significant GM diversity between patients with sleep disturbances versus healthy controls was found, revealed by α-diversity, while β-diversity is missing due to lack of proper reporting. However, probiotics supplementation significantly reduced the self-assessed parameter of sleep quality and disturbances Pittsburgh Sleep Quality Index (PSQI) score compared with the placebo. No difference in the Epworth Sleepiness Scale (ESS) score was found. While available data suggest that GM diversity is not related to sleep disturbances, probiotics administration strongly improves sleep quality as a subjective perception. However, heterogeneity of data reporting in the scientific literature should be considered as a limitation.

微生物群组成和益生菌补充剂对睡眠质量的影响--系统回顾和元分析。
肠道微生物群(GM)对人类健康起着至关重要的作用。肠道微生物群与中枢神经系统之间的双向互动可能是通过微生物群-肠道-大脑轴发生的,可能调节睡眠/觉醒周期。最近的报道强调了肠道菌群失调与睡眠障碍之间的联系,表明益生菌可以改善这种状况。然而,这方面的数据很少,而且不一致。这项定量元分析研究旨在评估睡眠障碍中的转基因成分,并评估益生菌对控制睡眠障碍的效果。截至 2022 年 7 月,我们在在线数据库中进行了系统性回顾,文献研究仅限于人类研究和英文文章。结果发现,睡眠障碍患者与健康对照组之间没有明显的基因组多样性差异,α-多样性显示了这一点,而β-多样性则由于缺乏适当的报告而缺失。然而,与安慰剂相比,补充益生菌能显著降低自我评估的睡眠质量参数和干扰匹兹堡睡眠质量指数(PSQI)得分。在埃普沃思嗜睡量表(ESS)得分方面没有发现差异。虽然现有数据表明转基因多样性与睡眠障碍无关,但作为一种主观感受,服用益生菌能显著改善睡眠质量。然而,科学文献中数据报告的异质性应被视为一个局限。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clocks & Sleep
Clocks & Sleep Multiple-
CiteScore
4.40
自引率
0.00%
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0
审稿时长
7 weeks
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