Unexplained subfertility: active or conservative management?

IF 1.1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-12-22 eCollection Date: 2023-12-01 DOI:10.1515/hmbci-2022-0087

Siti Maisarah Ahmad, Norazilah Mat Jin, Mohd Faizal Ahmad, Abdul Kadir Abdul Karim, Muhammad Azrai Abu

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引用次数: 0

Abstract

Objectives: Unexplained subfertility (UEI) describes a couple whose standard subfertility workout consider acceptable but unable to conceived.

Methods: This retrospective study was conducted in the Advanced Reproductive Centre, UKM Hospital, Kuala Lumpur, from January 2016 to December 2019. The data of 268 UEI couples were obtained from the clinical database. Women aged 21-45 years old was included and further divided into four groups according to the female partner's age and subfertility duration: group A (age <35 years and subfertility <2 years), group B (age <35 years and subfertility >2 years), group C (age >35 years and subfertility <2 years), and group D (age >35 years and subfertility <2 years). All statistical analyses were performed using SPSS 22.0 for Windows.

Results: A total of 255 cases were included in this study. The mean age of the women was 32.9 ± 4.04 years, and the mean subfertility duration was 5.04 ± 2.9 years. A total of 51 (20 %) cases underwent timed sexual intercourse, 147 (57.6 %) cases had intrauterine insemination (IUI), whereas 57 (22.4 %) cases opted for in vitro fertilization (IVF). A total of 204 cases underwent active management (IUI/IVF), which showed a significant difference (p<0.05). Out of eight clinical pregnancies, half of them were from group B.

Conclusions: Active management in younger women with a shorter subfertility duration revealed a better pregnancy outcome. Otherwise, individualized treatment should be considered in selecting a suitable treatment plan.

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不明原因的不孕症：积极治疗还是保守治疗？

目标：不明原因的不孕症（UEI）是指一对夫妇在标准的不孕症治疗过程中认为可以接受，但却无法受孕：这项回顾性研究于2016年1月至2019年12月在吉隆坡UKM医院高级生殖中心进行。从临床数据库中获取了268对UEI夫妇的数据。21-45岁的女性被纳入其中，并根据女性伴侣的年龄和亚不孕持续时间进一步分为四组：A组（年龄2岁）、C组（年龄>35岁且亚不孕35岁且亚不孕结果：本研究共纳入 255 个病例。妇女的平均年龄为（32.9 ± 4.04）岁，平均亚不孕时间为（5.04 ± 2.9）年。共有 51 人（20%）进行了定时性交，147 人（57.6%）进行了宫腔内人工授精（IUI），而 57 人（22.4%）选择了体外受精（IVF）。共有 204 个病例接受了积极治疗（人工授精/体外受精），两者之间存在显著差异（p 结论：对不孕症持续时间较短的年轻女性进行积极治疗，可获得更好的妊娠结果。否则，在选择合适的治疗方案时应考虑个体化治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.