Risk of Type 1 Diabetes Mellitus in Patients with Atopic Dermatitis: A Nationwide Population-Based Cohort Study.

IF 3 3区医学 Q2 DERMATOLOGY

Dermatology Pub Date : 2024-01-01 Epub Date: 2023-12-20 DOI:10.1159/000535848

Meng-Chieh Li, Chun-Ying Wu, Yun-Ting Chang, Ying-Syuan Lyu, Chen-Yi Wu

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引用次数: 0

Abstract

Introduction: Atopic dermatitis (AD) is a disease frequently occurring in children. The immune response is characterized by T-helper (Th)-2-dependent inflammation. Type 1 diabetes mellitus (T1DM) is an autoimmune disease that destroys pancreatic islet beta cells. In contrast, it is mainly mediated by a Th-1-dependent response. An inverted association has been hypothesized between T1DM and AD since Th1 and Th2 responses are mutually inhibitory.

Methods: Data was retrieved from a nationwide healthcare database in Taiwan. A logistic regression model was used to evaluate the association of T1DM in patients with AD within a year. A Cox proportional hazards analysis was used to evaluate the subsequent risk of developing T1DM 1 year after AD diagnosis.

Results: We identified 396,461 patients with AD and 1,585,844 age- and sex-matched controls. During the first year of follow-up, after adjusting variates, the association between T1DM and AD showed no statistical differences (odds ratio: 1.40; 95% confidence interval [CI]: 0.83-2.38, p = 0.207). After excluding those T1DM cases within 1 year of AD diagnosis and those with a follow-up duration of less than 1 year, AD did not significantly increase the risk of T1DM (hazard ratio [HR]: 1.02; 95% CI, 0.83-1.25, p = 0.843).

Conclusions: Our study revealed that there was no significant association between AD and T1DM in the first year after AD diagnosis, and there was no increased risk of T1DM in AD patients in the average 5-year follow-up in our study.

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特应性皮炎患者罹患 1 型糖尿病的风险：一项基于全国人口的队列研究。

背景：特应性皮炎（AD）是一种常发于儿童的疾病。免疫反应的特点是 T 辅助细胞（Th）-2 依赖性炎症。1 型糖尿病（T1DM）是一种破坏胰岛β细胞的自身免疫性疾病。与此相反，它主要是由 T 辅助细胞（Th）-1 依赖性反应介导的。由于Th1和Th2反应是相互抑制的，因此有人假设T1DM和AD之间存在反向关联：方法：数据取自台湾的全国医疗数据库。方法：数据来自台湾的一个全国性医疗保健数据库，采用逻辑回归模型评估一年内AD患者中T1DM的相关性。结果：我们发现了 396,461 名 AD 患者，这些患者在 AD 确诊后一年内罹患 T1DM：我们确定了 396,461 名 AD 患者和 1,585,844 名年龄和性别匹配的对照组。在随访的第一年中，经调整变量后，T1DM 与 AD 之间的关系无统计学差异（几率比 [OR]：1.40；95% 置信区间 [CI]：0.83-2.38，P = 0.207）。在排除了确诊 AD 一年内的 T1DM 病例和随访时间少于一年的 T1DM 病例后，AD 并未显著增加 T1DM 的风险（危险比 [HR]：1.02；95% 置信区间 [CI]：0.83-1.25，P = 0.843）：我们的研究表明，在AD确诊后的第一年内，AD与T1DM之间没有明显关联，此后AD患者罹患T1DM的风险也没有增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatology 医学-皮肤病学

CiteScore

6.40

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Published since 1893, ''Dermatology'' provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to ''Dermatology''. ''Dermatology'' answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation with a continually increasing impact factor and an equally high circulation.