Dynamical alterations of brain function and gut microbiome in weight loss

IF 4.6 2区医学 Q2 IMMUNOLOGY

Frontiers in Cellular and Infection Microbiology Pub Date : 2023-12-20 DOI:10.3389/fcimb.2023.1269548

Jing Zhou, Xiaoling Wu, Tianyuan Xiang, Fei Liu, Hui Gao, Li Tong, Bin Yan, Zhonglin Li, Chi Zhang, Linyuan Wang, Lei Ou, Zhongxia Li, Wen Wang, Tingting Yang, Fengyun Li, Huimin Ma, Xiaojuan Zhao, Na Mi, Ziya Yu, Canhui Lan, Qi Wang, Hao Li, Liming Wang, Xiaoning Wang, Yongli Li, Qiang Zeng

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引用次数: 0

Abstract

ObjectiveIntermittent energy restriction (IER) is an effective weight loss strategy. However, little is known about the dynamic effects of IER on the brain-gut-microbiome axis.MethodsIn this study, a total of 25 obese individuals successfully lost weight after a 2-month IER intervention. FMRI was used to determine the activity of brain regions. Metagenomic sequencing was performed to identify differentially abundant gut microbes and pathways in from fecal samples.ResultsOur results showed that IER longitudinally reduced the activity of obese-related brain regions at different timepoints, including the inferior frontal orbital gyrus in the cognitive control circuit, the putamen in the emotion and learning circuit, and the anterior cingulate cortex in the sensory circuit. IER longitudinally reduced E. coli abundance across multiple timepoints while elevating the abundance of obesity-related Faecalibacterium prausnitzii, Parabacteroides distasonis, and Bacterokles uniformis. Correlation analysis revealed longitudinally correlations between gut bacteria abundance alterations and brain activity changes.ConclusionsThere was dynamical alteration of BGM axis (the communication of E. coli with specific brain regions) during the weight loss under the IER.

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减肥过程中大脑功能和肠道微生物群的动态变化

目的间歇性能量限制（IER）是一种有效的减肥策略。方法在这项研究中，共有 25 名肥胖者在接受了为期 2 个月的间歇性能量限制干预后成功减轻了体重。研究使用核磁共振成像（FMRI）测定大脑区域的活动。结果我们的研究结果表明，IER能纵向降低肥胖相关脑区在不同时间点的活性，包括认知控制回路中的额下眶回、情绪和学习回路中的普坦门以及感觉回路中的前扣带皮层。IER在多个时间点上纵向降低了大肠杆菌的丰度，同时提高了与肥胖相关的普氏粪杆菌（Faecalibacterium prausnitzii）、远端副杆菌（Parabacteroides distasonis）和均匀杆菌（Bacterokles uniformis）的丰度。相关性分析表明，肠道细菌丰度变化与大脑活动变化之间存在纵向相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cellular and Infection Microbiology IMMUNOLOGY-MICROBIOLOGY

CiteScore

7.90

自引率

7.00%

发文量

1817

审稿时长

14 weeks

期刊介绍： Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.