IgG4-related pancreatobiliary diseases could be associated with onset of pancreatobiliary cancer: A multicenter cohort study

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2023-12-20 DOI:10.1002/jhbp.1404

Yusuke Kurita, Kensuke Kubota, Yuji Fujita, Seitaro Tsujino, Yusuke Sekino, Noriki Kasuga, Akito Iwasaki, Mai Iwase, Takeshi Izuka, Koichi Kagawa, Emiko Tanida, Shin Yagi, Sho Hasegawa, Takamitsu Sato, Kunihiro Hosono, Noritoshi Kobayashi, Yasushi Ichikawa, Atsushi Nakajima, Itaru Endo

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引用次数: 0

Abstract

Background

The risk and prognosis of pancreatobiliary cancer and in patients with autoimmune pancreatitis (AIP) and IgG4-related sclerosing cholangitis (IgG4-SC) remain unclear. Therefore, we retrospectively investigated the risk of pancreatobiliary cancer and prognosis in patients with AIP and IgG4-SC.

Methods

Patients with AIP and IgG4-SC at seven centers between 1998 and 2022 were investigated. The following data were evaluated: (1) the number of cancers diagnosed and standardized incidence ratio (SIR) for pancreatobiliary and other cancers during the observational period and (2) prognosis after diagnosis of AIP and IgG4-SC using standardized mortality ratio (SMR).

Results

This study included 201 patients with AIP and IgG4-SC. The mean follow-up period was 5.7 years. Seven cases of pancreatic cancer were diagnosed, and the SIR was 8.11 (95% confidence interval [CI]: 7.29–9.13). Three cases of bile duct cancer were diagnosed, and the SIR was 6.89 (95% CI: 6.20–7.75). The SMR after the diagnosis of AIP and IgG4-SC in cases that developed pancreatobiliary cancer were 4.03 (95% CI: 2.83–6.99).

Conclusions

Patients with autoimmune pancreatitis and IgG4-SC were associated with a high risk of pancreatic and bile duct cancer. Patients with AIP and IgG4-SC have a worse prognosis when they develop pancreatobiliary cancer.

查看原文本刊更多论文

IgG4相关的胰胆疾病可能与胰胆癌的发病有关：一项多中心队列研究

自身免疫性胰腺炎（AIP）和 IgG4 相关硬化性胆管炎（IgG4-SC）患者患胰胆管癌的风险和预后仍不清楚。因此，我们对自身免疫性胰腺炎（AIP）和 IgG4-SC 患者胰胆管癌的风险和预后进行了回顾性研究。

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