Mapping the genetic and phenotypic landscape of neonatal C3 and C4 protein concentrations.

Abstract

The complement system is crucial for innate immunity and has been linked to autoimmune and psychiatric disorders. Borbye-Lorenzen et al.¹ perform GWASs and PheWASs of neonatal C3/C4 protein concentrations, finding multiple genome-wide significant loci, and identify sex-specific associations between C3 protein concentration and C4 copy number with risk for schizophrenia.