Cardiac Amyloidosis: Clinical Features, Pathogenesis, Diagnosis, and Treatment.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.5146/tjpath.2023.12923

Asuman Argon, Deniz Nart, Funda Yilmazbarbet

引用次数: 0

Abstract

Cardiac amyloidosis is a type of amyloidosis that deserves special attention as organ involvement significantly worsens the prognosis. Cardiac amyloidosis can be grouped under three main headings: immunoglobulin light chain (AL) amyloidosis that is dependent on amyloidogenic monoclonal light chain production; hereditary Transthyretin (TTR) amyloidosis that results from accumulation of mutated TTR; and wild-type (non-hereditary) TTR amyloidosis formerly known as senile amyloidosis. Although all three types cause morbidity and mortality due to severe heart failure when untreated, they contain differences in their pathogenesis, clinical findings, and treatment. In this article, the clinical features, pathogenesis, diagnosis, and treatment methods of cardiac amyloidosis will be explained with an overview, and an awareness will be raised in the diagnosis of this disease.

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心脏淀粉样变性：临床特征、发病机制、诊断和治疗》。

心脏淀粉样变性是一种值得特别关注的淀粉样变性，因为器官受累会使预后明显恶化。心脏淀粉样变性可分为三大类：免疫球蛋白轻链（AL）淀粉样变性，依赖于淀粉样单克隆轻链的产生；遗传性TTR淀粉样变性，由突变的TTR积聚所致；野生型（非遗传性）TTR淀粉样变性，以前称为老年性淀粉样变性。虽然这三种类型在未经治疗的情况下都会因严重心力衰竭而导致发病和死亡，但它们在发病机制、临床表现和治疗方法上存在差异。本文将概述心脏淀粉样变性的临床特征、发病机制、诊断和治疗方法，并提高对该病诊断的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.